Ahsan F, Rashid H, Eng C, Bennett D M, Ah-See K W
Department of ENT, Ward 45, Aberdeen Royal Infirmary, Foresterhill Road, Aberdeen AB25 2ZN, UK.
Clin Otolaryngol. 2007 Feb;32(1):24-7. doi: 10.1111/j.1365-2273.2007.01381.x.
Traditionally secondary post-tonsillectomy haemorrhage has been thought to be due to post-operative infection and as such is treated with broad-spectrum antibiotics. The aim of this study was to identify clinical evidence of infection in patients with secondary post-tonsillectomy haemorrhage that might justify the use of antibiotics in these patients.
Prospective data collection.
Tertiary University Teaching Hospital.
Adult patients admitted with post-tonsillectomy haemorrhage over a 2-year period.
Temperature, white cell count, Neutrophil count and C-reactive protein.
47 patients were admitted with secondary post-tonsillectomy haemorrhage. Fifteen out of 47 patients (32%) had an elevated white cell count but in them the other indicators of temperature and C-reactive protein were extremely variable: none of these 15 patients was pyrexial (> 37.6 C). An elevated C-reactive protein was found in 55% of patients but none had an elevated white cell count. The elevated C-reactive protein may have been influenced by the recent surgery rather than infection. Overall there was no clear interrelation between the indicators of infection in the patients and none had the three main indicators of infection (pyrexia, increased white cell count and elevated C-reactive protein).
Our results suggest that clinical signs of infection are lacking in patients with secondary tonsillectomy bleeding. Correspondingly the routine use of antibiotics should be questioned for secondary tonsillectomy haemorrhage.
传统上认为扁桃体切除术后继发性出血是由术后感染引起的,因此使用广谱抗生素进行治疗。本研究的目的是确定扁桃体切除术后继发性出血患者感染的临床证据,以证明这些患者使用抗生素的合理性。
前瞻性数据收集。
三级大学教学医院。
在两年期间因扁桃体切除术后出血入院的成年患者。
体温、白细胞计数、中性粒细胞计数和C反应蛋白。
47例患者因扁桃体切除术后继发性出血入院。47例患者中有15例(32%)白细胞计数升高,但其中体温和C反应蛋白的其他指标变化极大:这15例患者均无发热(>37.6℃)。55%的患者C反应蛋白升高,但无一例白细胞计数升高。C反应蛋白升高可能受近期手术影响而非感染。总体而言,患者感染指标之间无明显关联,且无一例患者具备感染的三个主要指标(发热、白细胞计数增加和C反应蛋白升高)。
我们的结果表明,扁桃体切除术后继发性出血患者缺乏感染的临床体征。相应地,对于扁桃体切除术后继发性出血常规使用抗生素应受到质疑。