Aghamohammadi Asghar, Farhoudi A, Moin M, Pourpak Zahra, Rezaei N, Nikzad M, Movahedi M, Gharagozlou M, Atarod Lida, Ahmadi Afshar Akefeh, Bazargan Nasrin, Abolmaali K, Mahmoudi Maryam
Department of Immunology and Allergy, Children’s Medical Center, Tehran University of Medical Sciences, Tehran, Iran.
Iran J Allergy Asthma Immunol. 2003 Sep;2(3):121-6.
Long-term intravenous immunoglobulin (IVIG) infusion is an effective treatment for children with humoral immunodeficiencies, already be complicated by systemic adverse effects. In order to determine the adverse effects of intravenous immunoglobulin in patients with antibody deficiency, 45 immunodeficient patients receiving intravenous immunoglobulin were studied during a 36 month period at Children's Medical Center. The investigated group included 25 patients with common variable immunodeficiency, 14 patients with X-linked agammaglobulinemia and 6 patients with IgG subclass deficiency. A total of fifty adverse effects occurred through 955 infusions (5.2%). The most frequent immediate adverse effects were mild (40 infusions out of 955) in 22 cases, including: chills, flushing, fever, nausea and headache. Three patients experienced moderate effects (10 infusions out of 955) such as rash, severe headache, joint pain and chest tightness. None of the effects was anaphylactic type. It can be concluded that intravenous immunoglobulin is generally a well-tolerated medical agent for patients with antibody deficiency, but all patients should be monitored by a physician who is familiar with its indications, risks, adverse effects and their appropriate management.
长期静脉注射免疫球蛋白（IVIG）输注是治疗体液免疫缺陷儿童的有效方法，但已出现全身性不良反应。为了确定静脉注射免疫球蛋白对抗体缺乏患者的不良反应，在儿童医学中心对45例接受静脉注射免疫球蛋白的免疫缺陷患者进行了为期36个月的研究。研究组包括25例常见变异型免疫缺陷患者、14例X连锁无丙种球蛋白血症患者和6例IgG亚类缺乏患者。在955次输注中总共出现了50次不良反应（5.2%）。最常见的即刻不良反应为轻度（955次输注中有40次），共22例，包括：寒战、潮红、发热、恶心和头痛。3例患者出现中度不良反应（955次输注中有10次），如皮疹、严重头痛、关节疼痛和胸闷。所有不良反应均非过敏型。可以得出结论，静脉注射免疫球蛋白对抗体缺乏患者通常是一种耐受性良好的药物，但所有患者都应由熟悉其适应证、风险、不良反应及其适当处理方法的医生进行监测。
