膀胱研究的未来：分子图谱、新药物靶点、基因治疗与组织工程 - Suppr

The future of bladder research: molecular profiling, new drug targets, gene therapy, and tissue engineering.

作者信息

Christ George, Andersson Karl-Erik, Atala Anthony

机构信息

Wake Forest Institute for Regenerative Medicine, Wake Forest University School of Medicine, BRF1 Building, Room 442, Medical Center Blvd., Winston Salem, NC, 27157, USA.

出版信息

Curr Urol Rep. 2007 Mar;8(2):95-9. doi: 10.1007/s11934-007-0056-y.

DOI:10.1007/s11934-007-0056-y

PMID:17303012

Abstract

摘要

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The future of bladder research: molecular profiling, new drug targets, gene therapy, and tissue engineering.

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Update on phosphodiesterase (PDE) isoenzymes as pharmacologic targets in urology: present and future.

Eur Urol. 2006 Dec;50(6):1194-207; discussion 1207. doi: 10.1016/j.eururo.2006.05.025. Epub 2006 Jun 6.

Recent applications of regenerative medicine to urologic structures and related tissues.

Curr Opin Urol. 2006 Jul;16(4):305-9. doi: 10.1097/01.mou.0000232055.20084.f6.

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Tissue Eng. 2006 Apr;12(4):635-44. doi: 10.1089/ten.2006.12.635.

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Lancet. 2006 Apr 15;367(9518):1241-6. doi: 10.1016/S0140-6736(06)68438-9.

Mechanisms of disease: role of purinergic signaling in the pathophysiology of bladder dysfunction.

Nat Clin Pract Urol. 2006 Apr;3(4):206-15. doi: 10.1038/ncpuro0456.

A shifted paradigm for the further understanding, evaluation, and treatment of lower urinary tract symptoms in men: focus on the bladder.

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The future of bladder research: molecular profiling, new drug targets, gene therapy, and tissue engineering.

Curr Urol Rep. 2007 Mar;8(2):95-9. doi: 10.1007/s11934-007-0056-y.

Regenerative medicine and urology.

BJU Int. 2003 Oct;92 Suppl 1:58-67. doi: 10.1046/j.1464-410x.92.s1.15.x.

Current formulations and techniques of drug/gene delivery for targeted therapy and tissue engineering.

Curr Pharm Des. 2010 Jul;16(21):2296-7. doi: 10.2174/138161210791920513.

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BJU Int. 2001 Nov;88(7):765-70. doi: 10.1046/j.1464-4096.2001.atala.2467.x.

Editorial: Nanotechnology for advanced therapy and diagnosis.

Biomed Microdevices. 2004 Jun;6(2):101-3. doi: 10.1023/b:bmmd.0000031745.64314.2e.

Gene therapy and tissue engineering for urologic dysfunction: status and prospects.

Mol Urol. 2001 Summer;5(2):67-70. doi: 10.1089/109153601300177574.

Recent advances in intravesical drug/gene delivery.

Mol Pharm. 2006 Jul-Aug;3(4):369-79. doi: 10.1021/mp060001j.

Future trends in bladder reconstructive surgery.

Semin Pediatr Surg. 2002 May;11(2):134-42. doi: 10.1053/spsu.2002.31812.

Gene therapy of bladder pain with herpes simplex virus (HSV) vectors expressing preproenkephalin (PPE).

Urology. 2001 Jun;57(6 Suppl 1):116. doi: 10.1016/s0090-4295(01)01060-3.

Engineering functional bladder tissues.

J Tissue Eng Regen Med. 2013 Jul;7(7):515-22. doi: 10.1002/term.547. Epub 2012 Mar 21.

引用本文的文献

Bladder smooth muscle organ culture preparation maintains the contractile phenotype.

Am J Physiol Renal Physiol. 2012 Nov 1;303(9):F1382-97. doi: 10.1152/ajprenal.00261.2011. Epub 2012 Aug 15.

本文引用的文献

Using gene chips to identify organ-specific, smooth muscle responses to experimental diabetes: potential applications to urological diseases.

BJU Int. 2007 Feb;99(2):418-430. doi: 10.1111/j.1464-410X.2007.06676.x.

Rho kinase: a target for treating urinary bladder dysfunction?

Trends Pharmacol Sci. 2006 Sep;27(9):492-7. doi: 10.1016/j.tips.2006.07.002. Epub 2006 Jul 25.

Update on phosphodiesterase (PDE) isoenzymes as pharmacologic targets in urology: present and future.

Eur Urol. 2006 Dec;50(6):1194-207; discussion 1207. doi: 10.1016/j.eururo.2006.05.025. Epub 2006 Jun 6.

Recent applications of regenerative medicine to urologic structures and related tissues.

Curr Opin Urol. 2006 Jul;16(4):305-9. doi: 10.1097/01.mou.0000232055.20084.f6.

TRPV1 (vanilloid receptor) in the urinary tract: expression, function and clinical applications.

Naunyn Schmiedebergs Arch Pharmacol. 2006 Jul;373(4):287-99. doi: 10.1007/s00210-006-0073-2. Epub 2006 May 24.

Review: tissue engineering of the urinary bladder: considering structure-function relationships and the role of mechanotransduction.

Tissue Eng. 2006 Apr;12(4):635-44. doi: 10.1089/ten.2006.12.635.

Tissue-engineered autologous bladders for patients needing cystoplasty.

Lancet. 2006 Apr 15;367(9518):1241-6. doi: 10.1016/S0140-6736(06)68438-9.

Mechanisms of disease: role of purinergic signaling in the pathophysiology of bladder dysfunction.

Nat Clin Pract Urol. 2006 Apr;3(4):206-15. doi: 10.1038/ncpuro0456.

A shifted paradigm for the further understanding, evaluation, and treatment of lower urinary tract symptoms in men: focus on the bladder.

Eur Urol. 2006 Apr;49(4):651-8. doi: 10.1016/j.eururo.2006.02.018. Epub 2006 Feb 17.

Purinoceptors as therapeutic targets for lower urinary tract dysfunction.

Br J Pharmacol. 2006 Feb;147 Suppl 2(Suppl 2):S132-43. doi: 10.1038/sj.bjp.0706637.

The future of bladder research: molecular profiling, new drug targets, gene therapy, and tissue engineering.

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The future of bladder research: molecular profiling, new drug targets, gene therapy, and tissue engineering.

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