de Pooter Renée, Zúñiga-Pflücker Juan Carlos
Department of Immunology, University of Toronto, Sunnybrook Research Institute, 2075 Bayview Avenue, Toronto, ON M4N 3M5, Canada.
Curr Opin Immunol. 2007 Apr;19(2):163-8. doi: 10.1016/j.coi.2007.02.011. Epub 2007 Feb 15.
In vivo, T cells develop in the thymus from bone marrow-derived hematopoietic progenitors. Similarly, T cells can develop in vitro in model systems that mimic thymic function. The recent development of the OP9-DL1 cell culture system, a two-dimensional T-inductive environment, has provided greater access to the processes of commitment and development in T lymphocytes.
在体内，T细胞由骨髓来源的造血祖细胞在胸腺中发育。同样，T细胞也能在模拟胸腺功能的体外模型系统中发育。OP9-DL1细胞培养系统作为一种二维T诱导环境，其最新进展为深入了解T淋巴细胞的定向分化和发育过程提供了更多机会。
