Choi Se Joon, Kim Ki Jung, Cho Hyeong Seok, Kim Seong Yun, Cho Young Jin, Hahn Sang June, Sung Ki-Wug
Department of Pharmacology, College of Medicine, The Catholic University of Korea, 505 Banpo-dong, Seocho-gu, Seoul 137-701, South Korea.
Alcohol. 2006 Oct;40(2):95-101. doi: 10.1016/j.alcohol.2006.12.004.
The purpose of this study was to examine the effects of ethanol on synaptic transmission in the dorsal striatum in rat brain slices. The effects of ethanol on corticostriatal synaptic transmission were tested by whole-cell voltage-clamp recording. Ethanol significantly decreased corticostriatal excitatory postsynaptic currents (EPSCs) in a dose-dependent manner (10-200 mM). However, the paired-pulse ratio was not affected by the ethanol (100 mM) treatment. The amplitude of miniature EPSCs (mEPSCs) from these neurons, recorded without cortical stimulation, was decreased, but the frequency of the mEPSCs remained unchanged. Ethanol also decreased currents induced by the local pressure injection of glutamate into dorsal striatal neurons. These results suggest that ethanol inhibits glutamatergic synaptic transmission in the dorsal striatum, possibly through a postsynaptic mechanism.
本研究的目的是检测乙醇对大鼠脑片背侧纹状体突触传递的影响。通过全细胞膜片钳记录来测试乙醇对皮质-纹状体突触传递的影响。乙醇以剂量依赖性方式（10 - 200 mM）显著降低皮质-纹状体兴奋性突触后电流（EPSCs）。然而，乙醇（100 mM）处理对配对脉冲比率没有影响。在没有皮质刺激的情况下记录的这些神经元的微小兴奋性突触后电流（mEPSCs）的幅度降低，但mEPSCs的频率保持不变。乙醇还降低了通过向背侧纹状体神经元局部压力注射谷氨酸所诱导的电流。这些结果表明，乙醇可能通过一种突触后机制抑制背侧纹状体中的谷氨酸能突触传递。
Zotero 插件