内皮型一氧化氮合酶在慢性炎症和癌症中的新作用。

An emerging role for endothelial nitric oxide synthase in chronic inflammation and cancer.

作者信息

Ying Lei, Hofseth Lorne J

机构信息

Department of Basic Pharmaceutical Sciences, South Carolina College of Pharmacy, University of South Carolina, 770 Sumter Street, Columbia, SC 29208, USA.

出版信息

Cancer Res. 2007 Feb 15;67(4):1407-10. doi: 10.1158/0008-5472.CAN-06-2149.

DOI:10.1158/0008-5472.CAN-06-2149

PMID:17308075

Abstract

Nitric oxide (NO) is a free radical that is involved in carcinogenesis. Recent literature indicates that endothelial NO synthase (eNOS) can modulate cancer-related events (angiogenesis, apoptosis, cell cycle, invasion, and metastasis). We review the literature linking eNOS to carcinogenesis to encourage future research assessing the role of eNOS in cancer prevention and treatment.

摘要

一氧化氮（NO）是一种参与致癌过程的自由基。近期文献表明，内皮型一氧化氮合酶（eNOS）可调节与癌症相关的事件（血管生成、细胞凋亡、细胞周期、侵袭和转移）。我们综述了将eNOS与致癌作用联系起来的文献，以鼓励未来开展评估eNOS在癌症预防和治疗中作用的研究。