圈养西部低地大猩猩（Gorilla gorilla gorilla）血脂谱的初步评估

Preliminary evaluation of blood lipid profiles in captive western lowland gorillas (Gorilla gorilla gorilla).

作者信息

Baitchman Eric J, Calle Paul P, Clippinger Tracy L, Deem Sharon L, James Stephanie B, Raphael Bonnie L, Cook Robert A

机构信息

Department of Clinical Care, Wildlife Health Sciences, Wildlife Conservation Society, 2300 Southern Boulevard, Bronx, New York 10460, USA.

出版信息

J Zoo Wildl Med. 2006 Jun;37(2):126-9. doi: 10.1638/05-064.1.

DOI:10.1638/05-064.1

PMID:17312789

Abstract

Published serum cholesterol values in captive western lowland gorillas (Gorilla gorilla gorilla) are much higher than human ranges, with a national mean of 7.36 mmol/L (284 mg/dl, n = 863). Complete blood lipid profiles were examined in 15 captive gorillas. High-density lipoprotein (HDL) was found to decrease more rapidly with age than total cholesterol, resulting in an increasing ratio of cholesterol HDL with age. The ratio of apolipoprotein B to apolipoprotein Al also increased with age. Establishment of a database of blood lipid values for captive gorillas with correlative analysis of animals with known atherosclerosis status may help to identify sensitive predictors of coronary heart disease risk.

摘要

圈养西部低地大猩猩（Gorilla gorilla gorilla）已公布的血清胆固醇值远高于人类范围，全国平均水平为7.36毫摩尔/升（284毫克/分升，n = 863）。对15只圈养大猩猩进行了全血脂谱检查。发现高密度脂蛋白（HDL）随年龄下降的速度比总胆固醇更快，导致胆固醇与HDL的比值随年龄增加。载脂蛋白B与载脂蛋白A1的比值也随年龄增加。建立圈养大猩猩血脂值数据库，并对已知动脉粥样硬化状态的动物进行相关分析，可能有助于识别冠心病风险的敏感预测指标。