[帕金森病丘脑底核刺激反应的预测性临床因素]
[Predictive clinical factors of response to subthalamic nucleus stimulation in Parkinson's disease].
作者信息
Garcia P J, Muñiz de Igneson J, Ayerbe J, Alonso Frech F, García Torres A, Contreras A, Magariños Ascone C
机构信息
Servicio de Neurología, Fundación Jiménez Díaz, Madrid, Spain.
出版信息
Neurologia. 2007 Jan-Feb;22(1):1-4.
INTRODUCTION
Subthalamic nucleus stimulation (SNE) is currently a reasonable treatment for patients with advanced Parkinson's disease (PD). Predictive factors for effective SNE have not yet been identified with precision. We have prospectively evaluated response to SNE in a series of patients with advanced PD to study the factors that influence clinical improvement after functional surgery.
METHODS
We prospectively studied 20 patients with advanced PD (age: 59 +/-6.1; stage: 3.0+/-0.8) candidates for SNE. We studied these patients preoperatively and 6 months postoperatively according to Core Assessment Program for Intracerebral Transplantation (CAPIT) protocol including timed tests.
CONCLUSIONS
We found a negative correlation between age and Unified Parkinson Disease Rating Scale (UPDRS) improvement; however, age did not correlate with timed tests improvement. In addition, preoperative severity (UPDRS and Hoehn-Yahr) did not correlate with UPDRS and timed tests improvement. In summary, age is a negative predictor for effective SNE.
引言
丘脑底核刺激（SNE）目前是晚期帕金森病（PD）患者的一种合理治疗方法。有效SNE的预测因素尚未精确确定。我们对一系列晚期PD患者的SNE反应进行了前瞻性评估，以研究影响功能手术后临床改善的因素。
方法
我们对20例晚期PD患者（年龄：59±6.1岁；分期：3.0±0.8期）进行了SNE治疗的前瞻性研究。我们根据脑内移植核心评估程序（CAPIT）方案，在术前和术后6个月对这些患者进行了研究，包括定时测试。
结论
我们发现年龄与统一帕金森病评定量表（UPDRS）改善之间呈负相关；然而，年龄与定时测试改善无关。此外，术前严重程度（UPDRS和Hoehn-Yahr分期）与UPDRS和定时测试改善无关。总之，年龄是有效SNE的负性预测因素。
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