McRae Simon J, Ginsberg Jeffrey S
Department of Medicine, McMaster University, Hamilton, ON, Canada.
Vasc Health Risk Manag. 2005;1(1):41-53. doi: 10.2147/vhrm.1.1.41.58936.
Anticoagulant therapy is effective at preventing the development of venous thromboembolism in high-risk patients, and reduces morbidity and mortality in individuals with established thromboembolic disease. Vitamin K antagonists and heparins are currently the most commonly used anticoagulant drugs, but they have practical limitations. Therefore, new antithrombotic agents with predictable dose-responses (thereby decreasing the need for monitoring without compromising efficacy or safety), ideally available in an oral formulation and with a rapidly reversible anticoagulant effect, are needed. New drugs fulfilling some of the above criteria have been developed and have proven to be effective agents for the treatment and prevention of venous thromboembolism.
抗凝治疗在预防高危患者发生静脉血栓栓塞方面有效,并可降低已确诊血栓栓塞性疾病患者的发病率和死亡率。维生素K拮抗剂和肝素是目前最常用的抗凝药物,但它们存在实际局限性。因此,需要新型抗血栓药物,其具有可预测的剂量反应(从而减少监测需求,同时不影响疗效或安全性),理想情况下为口服制剂且具有快速可逆的抗凝作用。已研发出符合上述部分标准的新药,并已证明是治疗和预防静脉血栓栓塞的有效药物。