Miyares Francisco Ruiz, Deleu Dirk, ElShafie Sittana S, Equia Frank, Mesraoua Boulenouar, Al Hail Hassan, Salim Khalid
Department of Neurology (Medicine), Hamad Medical Corporation, P.O. Box 3050, Doha, Qatar.
Clin Neurol Neurosurg. 2007 Jun;109(5):439-41. doi: 10.1016/j.clineuro.2007.01.010. Epub 2007 Feb 21.
A 35-year-old man presented with a meningeal syndrome and acute onset of visual blurring. Clinical investigations revealed bacterial meningitis with bilateral papillitis and ophthalmoparesis. Serum and cerebrospinal fluid serology confirmed the diagnosis of chronic active neurobrucellosis. Following therapy there was no improvement and he developed optic atrophy. Extensive literature review revealed, one case of bilateral irreversible papillitis resulting from neurobrucellosis. However no cases of neurobrucellosis have been reported with meningitis, irreversible papillitis and ophthalmoparesis. This case demonstrates that in endemic areas, acute meningitis is a potential manifestation of neurobrucellosis and that bilateral irreversible papillitis with ophthalmoparesis can be a potential serious complication.
一名35岁男性出现脑膜综合征并急性视力模糊。临床检查发现细菌性脑膜炎伴双侧视乳头炎和眼肌麻痹。血清和脑脊液血清学检查确诊为慢性活动性神经布鲁氏菌病。治疗后病情无改善，继而出现视神经萎缩。广泛的文献检索显示，有1例神经布鲁氏菌病导致双侧不可逆视乳头炎的病例。然而，尚无神经布鲁氏菌病合并脑膜炎、不可逆视乳头炎和眼肌麻痹的病例报道。该病例表明，在流行地区，急性脑膜炎可能是神经布鲁氏菌病的一种表现，双侧不可逆视乳头炎伴眼肌麻痹可能是一种潜在的严重并发症。
