单等位基因表达中的非编码RNA与核内定位

Noncoding RNAs and intranuclear positioning in monoallelic gene expression.

作者信息

Yang Pok Kwan, Kuroda Mitzi I

机构信息

Howard Hughes Medical Institute, Boston, Massachusetts 02115, USA.

出版信息

Cell. 2007 Feb 23;128(4):777-86. doi: 10.1016/j.cell.2007.01.032.

DOI:10.1016/j.cell.2007.01.032

PMID:17320513

Abstract

Mammalian X inactivation, imprinting, and allelic exclusion are classic examples of monoallelic gene expression. Two emerging themes are thought to be critical for monoallelic expression: (1) noncoding, often antisense, transcription linked to differential chromatin marks on otherwise homologous alleles and (2) physical segregation of alleles to separate domains within the nucleus. Here, we highlight recent progress in identifying these phenomena as possible key regulatory mechanisms of monoallelic expression.

摘要

哺乳动物的X染色体失活、印记和等位基因排斥是单等位基因表达的经典例子。两个新出现的主题被认为对单等位基因表达至关重要：（1）与原本同源等位基因上不同染色质标记相关的非编码转录，通常是反义转录；（2）等位基因在细胞核内物理分隔到不同区域。在这里，我们强调了在将这些现象确定为单等位基因表达可能的关键调控机制方面的最新进展。