食管癌患者的脑转移
Brain metastasis in patients with esophageal carcinoma.
作者信息
Yoshida Seiichi
机构信息
Department of Neurosurgery, Niigata Cancer Center Hospital, Niigata 951-8566, Japan.
出版信息
Surg Neurol. 2007 Mar;67(3):288-90. doi: 10.1016/j.surneu.2006.05.065. Epub 2006 Nov 3.
BACKGROUND
Brain metastasis from esophageal carcinoma is rare, and its natural history is unclear. To determine predictors for their outcomes, we conducted a retrospective review of patients.
METHODS
We treated 803 patients with metastatic brain tumors, and there were 17 patients with brain metastases from esophageal carcinoma. Their median age at the diagnosis was 57 years.
RESULTS
In the 15 patients with the pretreatment KPS of 70 or higher, the median survival after the diagnosis of brain metastasis was 26.2 months. Seven patients showed the median survival of 17.7 months after resection alone. The median survival was 65.5 months in the 3 patients who were treated with resection plus radiation.
CONCLUSIONS
Neurosurgical resection followed by WBRT seemed to be the indicated treatment in these patients.
背景
食管癌脑转移罕见，其自然病程尚不清楚。为确定其预后的预测因素，我们对患者进行了回顾性研究。
方法
我们治疗了803例转移性脑肿瘤患者，其中17例为食管癌脑转移患者。他们诊断时的中位年龄为57岁。
结果
15例治疗前KPS为70或更高的患者，脑转移诊断后的中位生存期为26.2个月。7例患者单纯切除术后的中位生存期为17.7个月。3例接受切除加放疗的患者中位生存期为65.5个月。
结论
对于这些患者，神经外科切除后行全脑放疗似乎是合适的治疗方法。
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