Daniel Gregory W, Malone Daniel C
University of Arizona, 1295 N. Martin, PO Box 210202, Tucson, AZ 85721-0202, USA.
J Manag Care Pharm. 2007 Mar;13(2):142-54. doi: 10.18553/jmcp.2007.13.2.142.
The Medicare Modernization Act of 2003 requires drug plan sponsors to provide medication therapy management programs (MTMPs) to beneficiaries with (1) drug expenditures above $4,000, (2) multiple comorbidities, and (3) multiple prescription drugs. The Medical Expenditure Panel Survey (MEPS) is a national probability survey conducted annually by the Agency for Healthcare Research and Quality and the National Center for Health Statistics to provide nationally representative estimates of health care use, expenditures, sources of payments, and insurance coverage for the U.S. civilian noninstitutionalized population. MEPS comprises 3 components, including the household component (HC) in which households and individuals within households are sampled. The medical provider component (MPC) supplements the HC by contacting providers (hospitals, outpatient offices, home health agencies, and pharmacies) reported in the HC, and the insurance component collects data on health insurance plans and is separate from the HC.
The purpose of this study was to estimate from MEPS data for 2002-2003 (1) the proportion of older adults who may have met the $4,000 expenditure component of the MTMP criteria and (2) the patient-specific risk factors associated with meeting the $4,000 expenditure threshold.
This study is a cross-sectional analysis of MEPS respondents aged 65 years or older. Data came from both the MEPS-HC and the supplemental MEPS-MPC for 2002 and 2003. Specific data files were pooled and included the Full Year Consolidated files, Prescribed Medicines files, and the Medical Conditions files for both the 2002 and the 2003 MEPS-HC. Variables extracted from the MEPS data files included demographics, socioeconomic status, functional limitations, health status, presence and number of chronic conditions, body mass index, medical and prescription drug insurance, and health care utilization measures. The expenditure threshold of $4,000 was adjusted to $3,810 in 2003 U.S. dollars. Survey-weighted logistic regression identified factors associated with meeting the expenditure threshold. Unbiased population point estimates were obtained by adjusting for survey nonresponse, poststratification, and oversampling of blacks and Hispanics using MEPS person-level weights. In all analyses, standard errors were adjusted for nonindependence of observations due to complex multistage sampling by specifying the strata and primary sampling units for each respondent.
Based on a sample of 8,035 noninstitutionalized persons aged 65 years or older in the United States, representing a population of 36.5 million older adults, MEPS data estimate that approximately 3.3 million (9.2%) incurred annual drug expenditures greater than $3,810, accounting for 35% of $55.3 billion in drug expenditures among all older adults. Older adults meeting the $3,810 prescription expenditure threshold reported an average 10.8 (SE=0.2) unique medications, 82.2 (SE=1.8) prescriptions, and 5.2 (SE=0.1) chronic conditions. Prescription expenditures accounted for 33.9% of total health care expenditures compared with 15.8% for persons who did not meet the $3,810 criterion and an average 19.5% for all persons aged 65 years or older (n=8,035). Factors that predicted meeting the expenditure threshold included age in 10-year increments (odds ratio [OR]=0.81; 95% confidence interval [CI], 0.68-0.97), requiring help with activities of daily living (OR=1.53; 95% CI, 1.19-1.97), having functional limitations (OR=1.67; 95% CI, 1.30-2.14), having TRICARE (military health care services) benefits (OR=0.54; 95% CI, 0.33-0.86), and being on Medicaid (OR=1.36; 95% CI, 1.02-1.81). Other factors that were also predictive of meeting the expenditure threshold included mental health disorders, ulcers, diabetes, dyslipidemia, cardiac disease, chronic obstructive pulmonary disorder, and the number of chronic conditions.
MEPS survey respondents aged 65 years or older with drug expenditures exceeding the MTMP threshold of $4,000 per year obtain substantially more drugs and have a higher disease burden than those with lower drug expenditures. Characteristics other than drug use, such as having functional limitations or requiring help with activities of daily living, can be used to identify potential MTMP candidates.
2003年的《医疗保险现代化法案》要求药品计划赞助商为符合以下条件的受益人提供药物治疗管理计划(MTMPs):(1)药品支出超过4000美元;(2)患有多种合并症;(3)使用多种处方药。医疗支出小组调查(MEPS)是由医疗保健研究与质量局和国家卫生统计中心每年进行的一项全国概率调查,旨在对美国非机构化平民人口的医疗保健使用、支出、支付来源和保险覆盖范围提供具有全国代表性的估计。MEPS包括3个部分,其中家庭部分(HC)对家庭及家庭中的个人进行抽样。医疗服务提供者部分(MPC)通过联系HC中报告的提供者(医院、门诊办公室、家庭健康机构和药房)对HC进行补充,保险部分收集有关健康保险计划的数据,且与HC分开。
本研究的目的是根据2002 - 2003年MEPS数据估计:(1)可能符合MTMP标准中4000美元支出标准的老年人比例;(2)与达到4000美元支出门槛相关的患者特定风险因素。
本研究是对65岁及以上MEPS受访者的横断面分析。数据来自2002年和2003年的MEPS - HC以及补充的MEPS - MPC。将特定数据文件合并,包括2002年和2003年MEPS - HC的全年合并文件、处方药文件和医疗状况文件。从MEPS数据文件中提取的变量包括人口统计学、社会经济地位、功能限制、健康状况、慢性病的存在情况和数量、体重指数、医疗和处方药保险以及医疗保健利用指标。4000美元的支出门槛调整为2003年美元的3810美元。采用调查加权逻辑回归确定与达到支出门槛相关的因素。通过使用MEPS个人层面权重对调查无应答、事后分层以及黑人和西班牙裔的过抽样进行调整,获得无偏总体点估计值。在所有分析中,通过为每个受访者指定分层和主要抽样单位,对由于复杂多阶段抽样导致的观测值非独立性进行标准误差调整。
基于美国8035名65岁及以上非机构化人员的样本,代表3650万老年人的总体,MEPS数据估计约330万(9.2%)老年人的年度药品支出超过3810美元,占所有老年人553亿美元药品支出的35%。达到3810美元处方支出门槛的老年人平均报告使用10.8种(标准误 = 0.2)独特药物、82.2张(标准误 = 1.8)处方和5.2种(标准误 = 0.1)慢性病。与未达到3810美元标准的人相比,处方支出占总医疗保健支出的33.9%,而所有65岁及以上人群(n = 8035)的这一比例平均为19.5%。预测达到支出门槛 的因素包括以10年为增量的年龄(优势比[OR]=0.81;95%置信区间[CI],0.68 - 0.97)、需要日常生活活动帮助(OR = 1.53;95% CI,1.19 - 1.97)、有功能限制(OR = 1.67;95% CI,1.30 - 2.14)、有TRICARE(军事医疗服务)福利(OR = 0.54;95% CI,0.33 - 0.86)以及参加医疗补助(OR = 1.36;95% CI,1.02 - 1.81)。其他也可预测达到支出门槛的因素包括精神健康障碍、溃疡、糖尿病、血脂异常、心脏病、慢性阻塞性肺疾病以及慢性病数量。
MEPS调查中65岁及以上且药品支出超过MTMP每年4000美元门槛的受访者比药品支出较低的受访者获得的药物显著更多,且疾病负担更高。除药物使用外的其他特征,如存在功能限制或需要日常生活活动帮助,可用于识别潜在的MTMP候选人。