[Itraconazole for treatment of fungal infections in patients undergoing allogeneic hematopoietic stem cell transplantation].

OBJECTIVE

To investigate the effect of intravenous itraconazole on fungal infections in patients undergoing allogeneic hematopoietic stem cell transplantation.

METHODS

Seventy-five such patients treated with itraconazole from October, 2002 to October, 2005 were studied. The diagnosis of fungal infection was made according to the criteria recommended by Chinese workshop on invasive fungal infection (IFI). Four patients were definitely diagnosed as IFI, twenty-two patients probably and 49 patients possibly.

RESULTS

Fifty-seven of the 75 patients showed response to itraconazole therapy including 3 definite, 18 probable and 36 possible cases.

CONCLUSION

Fungal infections in patients undergoing allogeneic stem cell transplantation diagnosed according to the criteria recommended by Chinese workshop on IFI can be successfully treated with itraconazole.