脑缺血后给予17β-雌二醇神经保护作用的剂量依赖性和治疗窗。
Dose dependence and therapeutic window for the neuroprotective effects of 17beta-estradiol when administered after cerebral ischemia.
作者信息
Liu Ran, Wang Xiaofei, Liu Qing, Yang Shao-Hua, Simpkins James W
机构信息
Department of Pharmacology and Neuroscience, University of North Texas Health Science Center, 3500 Camp Bowie Boulevard, Fort Worth, TX 76107, USA.
出版信息
Neurosci Lett. 2007 Mar 30;415(3):237-41. doi: 10.1016/j.neulet.2007.01.074. Epub 2007 Feb 14.
Abstract
The present study was undertaken to determine if the neuroprotective effect of 17beta-estradiol (E(2)) when administrated after ischemia is dose-dependent and if the therapeutic window for estrogen can be prolonged. Ischemic injury was induced by permanent middle cerebral artery occlusion (p-MCAO). Administration of E(2) at 30 min after ischemia resulted in a reduction in lesion volume. A higher dose of E(2) extended the therapeutic window to 6h after cerebral ischemia in 33% of the rats. These findings suggest that postischemic treatment with estrogen affords protection against ischemic damage and that it acts within a clinically useful therapeutic window.
摘要
本研究旨在确定缺血后给予17β-雌二醇（E₂）的神经保护作用是否具有剂量依赖性，以及雌激素的治疗窗是否可以延长。通过永久性大脑中动脉闭塞（p-MCAO）诱导缺血性损伤。缺血后30分钟给予E₂可使损伤体积减小。更高剂量的E₂可将33%的大鼠脑缺血治疗窗延长至6小时。这些发现表明，缺血后雌激素治疗可提供针对缺血性损伤的保护作用，且其作用于临床有用的治疗窗内。
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