Capoor Malini R, Nair Deepthi, Hasan Azra S, Aggarwal Pushpa, Gupta B
Department of Microbiology, Vardhman Mahaveer Medical College and Safdarjung Hospital, New Delhi, India.
Southeast Asian J Trop Med Public Health. 2006 Nov;37(6):1170-4.
Typhoid fever remains an important public health problem in India. One thousand four hundred fifty-eight blood cultures were screened, 178 grew out Salmonella enterica serovar Typhi. On agar dilution minimum inhibitory concentration (MIC) testing, 0.6% of the isolates were resistant to ciprofloxacin, 2% to cefotaxime and 1% to cefepime. Nalidixic acid resistance was observed in 51% isolates, of which 98.9% had decreased susceptibility (MIC > or = 0.125-4 microg/ml) to ciprofloxacin. One strain of nalidixic acid sensitive S. Typhi (NASST) also had a decreased MIC (0.125 microg/ml) to ciprofloxacin. Resistance to third and fourth generation cephalosporins is emerging in India and will gain significance in the coming decade. The molecular basis of resistance to cephalosporinsand ciprofloxacin resistance in NASST strains need to be further evaluated for S. Typhi.
伤寒热在印度仍然是一个重要的公共卫生问题。对1458份血培养样本进行了筛查，其中178份培养出肠炎沙门氏菌伤寒血清型。通过琼脂稀释法进行最低抑菌浓度（MIC）测试，0.6%的分离株对环丙沙星耐药，2%对头孢噻肟耐药，1%对头孢吡肟耐药。51%的分离株观察到对萘啶酸耐药，其中98.9%对环丙沙星的敏感性降低（MIC≥0.125 - 4微克/毫升）。一株对萘啶酸敏感的伤寒沙门氏菌（NASST）对环丙沙星的MIC也降低了（0.125微克/毫升）。在印度，对第三代和第四代头孢菌素的耐药性正在出现，并且在未来十年将变得更加重要。对于伤寒沙门氏菌，NASST菌株中对头孢菌素耐药和环丙沙星耐药的分子基础需要进一步评估。
