Notario A, Pallavicini E B, Marcianò S, Fortina A
Istituto di Clinica Medica Generale e Terapia Medica dell'Università di Pavia.
Arch Sci Med (Torino). 1973 Jul-Sep;130(3):169-87.
Serum and liver tissue fatty acid and lipid fraction values were studied in rats kept for various periods on a hyperlipid, hypoprotein, steatogenous diet, with or witout choline. There was a general increase in liver fats due to an absolute increase in triglycerides, accompanied by changes in the fatty acid methyl ester composition, indicating the storage of lipids of lesser metabolic activity and more similar to those of peripheral fat (palmitic and oleic acid increments; decreases in myristic, stearic, linoleic and arachidonic acid values). These changes were partly reflected in the blood picture: little difference in lipid fraction ratios, coupled with fatty acid gas chromatograms similar to those observed for the liver. The omission of choline aggravated the alterations caused by the experimental diet.
研究了在高脂、低蛋白、致脂肪肝饮食条件下饲养不同时期的大鼠的血清和肝脏组织脂肪酸及脂质组分值，饮食中添加或不添加胆碱。由于甘油三酯绝对含量增加，肝脏脂肪普遍增多，同时脂肪酸甲酯组成发生变化，表明代谢活性较低且更类似于外周脂肪的脂质得以储存（棕榈酸和油酸增加；肉豆蔻酸、硬脂酸、亚油酸和花生四烯酸值降低）。这些变化部分反映在血液指标中：脂质组分比例差异不大，同时脂肪酸气相色谱图与在肝脏中观察到的相似。胆碱的缺失加剧了实验饮食所导致的变化。
