绵羊静脉内、肌内和皮下注射双氟沙星后的药代动力学。

Pharmacokinetics after intravenous, intramuscular and subcutaneous administration of difloxacin in sheep.

作者信息

Marín P, Fernández-Varón E, Escudero E, Cárceles C M

机构信息

Department of Pharmacology, Faculty of Veterinary Medicine, University of Murcia, Campus de Espinardo, 30071 Murcia, Spain.

出版信息

Res Vet Sci. 2007 Oct;83(2):234-8. doi: 10.1016/j.rvsc.2007.01.005. Epub 2007 Mar 6.

DOI:10.1016/j.rvsc.2007.01.005

PMID:17343888

Abstract

The disposition kinetics of difloxacin, a fluoroquinolone antibiotic, after intravenous (IV), intramuscular (IM) and subcutaneous (SC) administration were determined in sheep at a single dose of 5mg/kg. The concentration-time data were analysed by compartmental (after IV dose) and non-compartmental pharmacokinetics method (after IV, IM and SC administration). Plasma concentrations of difloxacin were determined by high performance liquid chromatography with fluorescence detection. Steady-state volume of distribution (V(ss)) and clearance (Cl) of difloxacin after IV administration were 1.68+/-0.21L/kg and 0.21+/-0.03L/hkg, respectively. Following IM and SC administration difloxacin achieved maximum plasma concentration of 1.89+/-0.55 and 1.39+/-0.14mg/L at 2.42+/-1.28 and 5.33+/-1.03h, respectively. The absolute bioavailabilities after IM and SC routes were 99.92+/-26.50 and 82.35+/-25.65%, respectively. Based on these kinetic parameters, difloxacin is likely to be effective in sheep.

摘要

在绵羊中以5mg/kg的单剂量测定了氟喹诺酮类抗生素二氟沙星静脉注射（IV）、肌肉注射（IM）和皮下注射（SC）后的处置动力学。通过房室模型（静脉注射后）和非房室药代动力学方法（静脉注射、肌肉注射和皮下注射后）分析浓度-时间数据。采用高效液相色谱荧光检测法测定血浆中二氟沙星的浓度。静脉注射后二氟沙星的稳态分布容积（V(ss)）和清除率（Cl）分别为1.68±0.21L/kg和0.21±0.03L/hkg。肌肉注射和皮下注射后，二氟沙星分别在2.42±1.28小时和5.33±1.03小时达到最大血浆浓度1.89±0.55mg/L和1.39±0.14mg/L。肌肉注射和皮下注射途径后的绝对生物利用度分别为99.92±26.50%和82.35±25.65%。基于这些动力学参数，二氟沙星可能对绵羊有效。