Crossley Ellen L, Ziolkowski Erin J, Coderre Jeffrey A, Rendina Louis M
School of Chemistry, The University of Sydney, Sydney, NSW 2006, Australia.
Mini Rev Med Chem. 2007 Mar;7(3):303-13. doi: 10.2174/138955707780059808.
Boron Neutron Capture Therapy (BNCT) is a binary cancer treatment that exploits the short range particles released from a nuclear fission reaction involving the non-radioactive 10B nucleus and low-energy (thermal) neutrons for the destruction of tumour cells. If boronated agents are targeted towards chromosomal DNA, the efficiency of BNCT is greatly enhanced. This article presents a concise review of DNA-binding compounds that have been functionalised with boron.
硼中子俘获疗法（BNCT）是一种二元癌症治疗方法，它利用涉及非放射性10B核和低能（热）中子的核裂变反应释放的短程粒子来破坏肿瘤细胞。如果将含硼剂靶向染色体DNA，BNCT的效率会大大提高。本文简要综述了已用硼功能化的DNA结合化合物。
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