信号转导和转录激活因子1（STAT1）调节p73介导的Bax基因表达。

STAT1 regulates p73-mediated Bax gene expression.

作者信息

Soond Surinder M, Carroll Christopher, Townsend Paul A, Sayan Emre, Melino Gerry, Behrmann Iris, Knight Richard A, Latchman David S, Stephanou Anastasis

机构信息

Medical Molecular Biology Unit, Institute of Child Health, University College London, 30 Guilford Street, London WC1N 1EH, UK.

出版信息

FEBS Lett. 2007 Mar 20;581(6):1217-26. doi: 10.1016/j.febslet.2007.02.049. Epub 2007 Mar 1.

DOI:10.1016/j.febslet.2007.02.049

PMID:17346710

Abstract

Although signal transducer and activator of transcription 1 (STAT1) mediated regulation of p53 transcription and apoptosis has been previously reported, modulation of other members of the p53 family of transcription factors remains poorly understood. In this study, we found that STAT1 and TA-p73 can interact directly and that p73-mediated Bax promoter activity was observed to be reduced by STAT1 expression in a p53-independent manner for which STAT1 Tyrosine-701 and Serine-727 are key residues. This study presents the first report physically linking STAT1 and TA-p73 signalling and highlights the modulation of the Bax promoter in the context of IFN-gamma stimulation.

摘要

尽管此前已有报道称信号转导及转录激活因子1（STAT1）介导p53转录和凋亡的调控，但对p53转录因子家族其他成员的调控仍知之甚少。在本研究中，我们发现STAT1与TA-p73可直接相互作用，并且观察到STAT1的表达以一种不依赖p53的方式降低了p73介导的Bax启动子活性，其中STAT1的酪氨酸701和丝氨酸727是关键残基。本研究首次报道了STAT1与TA-p73信号之间的物理联系，并强调了在γ干扰素刺激背景下对Bax启动子的调控。