5-羟色胺1A受体介导的细胞凋亡：是由应激活化蛋白激酶导致的死亡吗？
5-HT1A receptor-mediated apoptosis: death by JNK?
作者信息
Meller Emanuel
机构信息
Millhauser Laboratories, Department of Psychiatry, New York University School of Medicine, New York, NY 10016, USA.
出版信息
Biochim Biophys Acta. 2007 Jun;1773(6):691-3. doi: 10.1016/j.bbamcr.2007.01.003. Epub 2007 Jan 10.
Abstract
There is growing interest in the potential use of 5-HT(1A) receptor agonists as neuroprotective agents in stroke and traumatic brain injury. However, a new study using a recombinant 5-HT(1A) receptor cell line suggests that these agonists may promote as well as inhibit apoptotic responses. Because heterologously expressed receptors may couple promiscuously to inappropriate signal transduction pathways, the results should be interpreted with caution.
摘要
5-羟色胺（5-HT）1A受体激动剂作为神经保护剂在中风和创伤性脑损伤中的潜在应用正受到越来越多的关注。然而，一项使用重组5-HT1A受体细胞系的新研究表明，这些激动剂可能既促进又抑制凋亡反应。由于异源表达的受体可能会随意地与不适当的信号转导途径偶联，因此对结果的解释应谨慎。
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本文引用的文献
1
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2
WAY-100635 antagonist-induced plasticity of 5-HT receptors: regulatory differences between a stable cell line and an in vivo native system.
J Neurochem. 2006 Jul;98(1):134-45. doi: 10.1111/j.1471-4159.2006.03883.x.
3
The effects of ethanol and the serotonin(1A) agonist ipsapirone on the expression of the serotonin(1A) receptor and several antiapoptotic proteins in fetal rhombencephalic neurons.
Brain Res. 2006 May 30;1092(1):79-86. doi: 10.1016/j.brainres.2006.02.065. Epub 2006 May 9.
4
5-HT1A receptor agonist-mediated protection from MPTP toxicity in mouse and macaque models of Parkinson's disease.
Neurobiol Dis. 2006 Jul;23(1):77-86. doi: 10.1016/j.nbd.2006.02.003. Epub 2006 Mar 20.
5
Differential profile of antipsychotics at serotonin 5-HT1A and dopamine D2S receptors coupled to extracellular signal-regulated kinase.
Eur J Pharmacol. 2006 Mar 18;534(1-3):63-70. doi: 10.1016/j.ejphar.2006.01.027. Epub 2006 Feb 21.
6
Roles of extracellular signal-regulated kinase and Akt signaling in coordinating nuclear transcription factor-kappaB-dependent cell survival after serotonin 1A receptor activation.
J Neurochem. 2005 Dec;95(6):1653-66. doi: 10.1111/j.1471-4159.2005.03496.x. Epub 2005 Oct 20.
7
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8
5-HT receptors couple to activation of Akt, but not extracellular-regulated kinase (ERK), in cultured hippocampal neurons.
J Neurochem. 2005 May;93(4):910-7. doi: 10.1111/j.1471-4159.2005.03107.x.
9
The BRAINS study: safety, tolerability, and dose-finding of repinotan in acute stroke.
Can J Neurol Sci. 2005 Feb;32(1):61-7. doi: 10.1017/s0317167100016899.
10
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