Ricklin Gutzwiller Meret E, Reist Martin, Peel John E, Seewald Wolfgang, Brunet Laura Rosa, Roosje Petra J
Division of Clinical Dermatology, Department of Clinical Veterinary Medicine, Vetsuisse Faculty, University of Berne, Berne, Switzerland.
Vet Dermatol. 2007 Apr;18(2):87-93. doi: 10.1111/j.1365-3164.2007.00579.x.
Canine atopic dermatitis (cAD) is a common disease with a multifactorial aetiology associated with impaired immunoregulation. The immunopathogenesis has similarities to that of human atopic dermatitis. Clinical signs of allergic disease in humans and mice are reduced by administration of saprophytic mycobacteria that amplify regulatory cytokines and hence the effect of Mycobacterium vaccae on the clinical severity of cAD was investigated. Sixty-two dogs with cAD, selected according to strict criteria, were treated with a single intradermal injection and evaluated monthly for 3 months in a placebo-controlled double-blind clinical trial. Clinical severity was quantified using standardized scores and by owner assessment of pruritus. A single injection of a heat-killed suspension of M. vaccae was found to be well tolerated and effective in treating mild to moderate cases of cAD demonstrable for 3 months, but was insignificant in more severely affected dogs.
犬特应性皮炎（cAD）是一种病因多因素且与免疫调节受损相关的常见疾病。其免疫发病机制与人类特应性皮炎相似。通过给予能增强调节性细胞因子的腐生分枝杆菌可减轻人类和小鼠过敏性疾病的临床症状，因此研究了母牛分枝杆菌对cAD临床严重程度的影响。在一项安慰剂对照双盲临床试验中，按照严格标准选取62只患有cAD的犬，进行单次皮内注射治疗，并在3个月内每月进行评估。使用标准化评分和主人对瘙痒的评估来量化临床严重程度。结果发现，单次注射热灭活的母牛分枝杆菌悬浮液耐受性良好，对治疗轻度至中度cAD病例有效，疗效可持续3个月，但对病情更严重的犬效果不显著。
