系统性红斑狼疮患者CD4 + T细胞受体ζ链缺陷的流式细胞术分析
Flow cytometric analysis of CD4+ T cell receptor zeta chain deficiency in patients with systemic lupus erythematosus.
作者信息
Duriagin S, Ofori H, Jagodziński P P
机构信息
Department of Biochemistry and Molecular Biology, Poznań University of Medical Sciences, Poland.
出版信息
Adv Med Sci. 2006;51:181-3.
PURPOSE
It has been reported that a dysfunction of T lymphocytes can be responsible for alteration in immune system in patients with systemic lupus erythematosus (SLE).
MATERIAL AND METHODS
Using flow cytometric analysis, we determined the abnormalities of T cell receptor zeta (TCR zeta) chain contents in CD4+ T cells of SLE patients.
RESULTS
We observed a decrease in mean fluorescence intensity of TCR zeta in CD4+ T cells of patients with SLE. The multiple analysis did not show a correlation between gender, age, disease specific manifestation, treatment, duration and TCR zeta mean fluorescence intensity in CD4+ T cells.
CONCLUSIONS
High prevalence of TCR zeta chain deficiency in CD4+ T cells confirms the significance of this signaling molecule in SLE pathogenesis.
目的
据报道，T淋巴细胞功能障碍可能是系统性红斑狼疮（SLE）患者免疫系统改变的原因。
材料与方法
采用流式细胞术分析，我们测定了SLE患者CD4 + T细胞中T细胞受体ζ（TCRζ）链含量的异常情况。
结果
我们观察到SLE患者CD4 + T细胞中TCRζ的平均荧光强度降低。多因素分析未显示性别、年龄、疾病特异性表现、治疗、病程与CD4 + T细胞中TCRζ平均荧光强度之间存在相关性。
结论
CD4 + T细胞中TCRζ链缺陷的高发生率证实了该信号分子在SLE发病机制中的重要性。
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