Ozmen B, Koutlaki N, Youssry M, Diedrich K, Al-Hasani S
Department of Obstetrics and Gynecology, University of Ankara, Ankara, Turkey.
Reprod Biomed Online. 2007 Mar;14(3):384-95. doi: 10.1016/s1472-6483(10)60883-8.
Sperm DNA contributes half the offspring's genomic material and abnormal DNA can lead to derangements in the reproductive process. Normal sperm genetic material is required for successful fertilization, as well as for further embryo and fetal development that will result in a healthy child. Thus, the damage to sperm DNA is critical in assisted reproductive techniques which are increasingly used to treat infertile couples. There has been improving data about the effects of human sperm DNA damage or fragmentation. As well, increasing knowledge concerning the effects of DNA damage on embryo and fetal development has been attained. This review aims to summarize the present knowledge on the impact of human sperm cell DNA damage on male infertility and outcome in the context of safety.
精子DNA贡献了后代一半的基因组物质，异常的DNA会导致生殖过程紊乱。正常的精子遗传物质是成功受精以及进一步胚胎和胎儿发育所必需的，而这将孕育出一个健康的孩子。因此，精子DNA损伤在越来越多地用于治疗不孕夫妇的辅助生殖技术中至关重要。关于人类精子DNA损伤或碎片化影响的数据一直在增加。此外，人们对DNA损伤对胚胎和胎儿发育影响的认识也在不断提高。本综述旨在总结目前关于人类精子细胞DNA损伤对男性不育及安全性方面结局影响的知识。
