OspC系统发育分析支持一种具有广泛保护作用的多价嵌合莱姆病疫苗的可行性。
OspC phylogenetic analyses support the feasibility of a broadly protective polyvalent chimeric Lyme disease vaccine.
作者信息
Earnhart Christopher G, Marconi Richard T
机构信息
Department of Microbiology and Immunology, Center for the Study of Biological Complexity, Medical College of Virginia at Virginia Commonwealth University, Richmond, VA 23298-0678, USA.
出版信息
Clin Vaccine Immunol. 2007 May;14(5):628-34. doi: 10.1128/CVI.00409-06. Epub 2007 Mar 14.
Abstract
Using available Borrelia outer surface protein C (OspC) sequences, a phylogenetic analysis was undertaken to delineate the number of antigenic domains required for inclusion in a broadly protective, chimeric, OspC-based Lyme disease vaccine. The data indicate that approximately 34 would be required and that an OspC-based vaccinogen is feasible.
摘要
利用现有的疏螺旋体表面蛋白C（OspC）序列进行系统发育分析，以确定一种广泛保护性的、嵌合的、基于OspC的莱姆病疫苗所需包含的抗原结构域数量。数据表明大约需要34个，且基于OspC的疫苗原是可行的。
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