Naess Halvor
Nevrologisk avdeling, Haukeland Universitetssjukehus, 5021 Bergen.
Tidsskr Nor Laegeforen. 2007 Mar 15;127(6):751-3.
Young patients with cerebral infarction may differ from old patients with regard to clinical and prognostic aspects, and this may have implications for clinical management.
The article is based on literature found on PubMed and results from the authors' population-based study of 232 patients (aged 15-49) with cerebral infarction in Hordaland, Norway.
The aetiology of cerebral infarction differs between young and old patients. Prothrombotic states and dissection are more frequent, while atherosclerosis is a relatively rare cause of cerebral infarction among young patients. After 6 years of follow-up in the Hordaland study; 9.9% of the patients had died, 9.9% had recurrence of cerebral infarction, and 10.5% had developed post-stroke seizures. Recurrence of cerebral infarction was strongly associated with the number of traditional risk factors. Even though most studies report that a majority of patients are functionally independent upon discharge from the hospital, many of these patients drop out of their jobs. The aetiology of the disease is unknown in a large proportion of young patients and it is not known why so many drop out of their jobs; future studies should address these issues.
年轻的脑梗死患者在临床和预后方面可能与老年患者有所不同,这可能对临床管理产生影响。
本文基于在PubMed上检索到的文献以及作者对挪威霍达兰郡232例年龄在15至49岁之间的脑梗死患者进行的基于人群的研究结果。
年轻患者和老年患者脑梗死的病因有所不同。血栓前状态和动脉夹层更为常见,而动脉粥样硬化在年轻患者中是相对少见的脑梗死病因。在霍达兰郡的研究进行6年随访后,9.9%的患者死亡,9.9%的患者脑梗死复发,10.5%的患者出现了卒中后癫痫发作。脑梗死复发与传统危险因素的数量密切相关。尽管大多数研究报告称,大多数患者出院时功能独立,但这些患者中有许多人失去了工作。在很大一部分年轻患者中,疾病病因不明,也不清楚为何如此多的患者失去工作;未来的研究应解决这些问题。