翼齿风毛菊中的倍半萜内酯

Sesquiterpene lactones from Saussurea alata.

作者信息

Ren G, Yu Z M, Chen Y L, Wu S H, Fu C X

机构信息

Research Centre of Siyuan Natural Pharmacy and Bio-toxicity, College of Life Sciences, Zhejiang University, Hangzhou 310058, China.

出版信息

Nat Prod Res. 2007 Mar;21(3):221-6. doi: 10.1080/14786410601130752.

DOI:10.1080/14786410601130752

PMID:17365712

Abstract

Two new guaianolides, namely, 3beta,8alpha-dihydroxy-13-methoxyl-4(14),10(15)-dien-(1alphaH,5alphaH,6beta H,11betaH)-12,6-olide (1) and 3beta,8alpha-dihydroxy-13-methoxyl-4(14),10(15)-dien-(1alphaH,5alphaH,6beta H,11alphaH)-12,6-olide (2), together with six known guaianolides, 8-hydroxyzaluzanin C, austricin, chlorojanerin, cynaropicrin, chlorohyssopifolin E and chlorohyssopifolin A were isolated from the aerial parts of Saussurea alata. The structures were established mainly based on spectral analysis, especially 2D NMR techniques.

摘要

从翼齿风毛菊的地上部分分离得到两个新的愈创木内酯，即3β,8α-二羟基-13-甲氧基-4(14),10(15)-二烯-(1αH,5αH,6βH,11βH)-12,6-内酯（1）和3β,8α-二羟基-13-甲氧基-4(14),10(15)-二烯-(1αH,5αH,6βH,11αH)-12,6-内酯（2），以及六个已知的愈创木内酯，8-羟基扎鲁扎宁C、奥斯特里辛、氯贾内里宁、绿原酸、氯鼠尾草酸E和氯鼠尾草酸A。结构主要通过光谱分析确定，尤其是二维核磁共振技术。