丙硫氧嘧啶诱发的与抗中性粒细胞胞浆抗体相关的血管炎：一例报告

Propylthiouracil-induced vasculitis associated with ANCA: a case report.

作者信息

Yuksel Cuneyt, Ayli M Deniz, Yuksel Aydan, Atilgan K Gokhan, Dede Fatih, Guler Serdar, Memis Leyla, Duranay Murat

机构信息

Ankara Numune Education and Research Hospital, Nephrology Clinic, Ankara, Turkey.

出版信息

Ren Fail. 2007;29(2):235-7. doi: 10.1080/08860220601098987.

DOI:10.1080/08860220601098987

PMID:17365943

Abstract

Propylthiouracil is a drug used in the treatment of hyperthyroidism for more than 60 years. Adverse side effects are seen in 1-5% of patients. Renal complications of the drug including glomerulonephritis and vasculitis are rarely seen. Cases of propylthiouracil-induced rapidly progressive glomerulonephritis and vasculitis are reported in association with antineutrophil cytoplasmic autoantibodies. Here we report a case of positive antineutrophil cytoplasmic autoantibodies rapidly progressive glomerulonephritis (RPGN) associated with propylthiouracil treatment.

摘要

丙硫氧嘧啶是一种用于治疗甲状腺功能亢进症超过60年的药物。1%至5%的患者会出现不良反应。该药物的肾脏并发症，包括肾小球肾炎和血管炎，较为罕见。有报告称丙硫氧嘧啶诱发的快速进展性肾小球肾炎和血管炎病例与抗中性粒细胞胞浆自身抗体有关。在此，我们报告一例与丙硫氧嘧啶治疗相关的抗中性粒细胞胞浆自身抗体阳性快速进展性肾小球肾炎（RPGN）病例。