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爱尔兰普通科就诊吸毒者丙型肝炎的管理:都柏林地区普通科丙型肝炎倡议的基线数据

Management of hepatitis C among drug users attending general practice in Ireland: baseline data from the Dublin area hepatitis C in general practice initiative.

作者信息

Cullen Walter, Stanley June, Langton Deirdre, Kelly Yvonne, Bury Gerard

机构信息

UCD School of Medicine and Medical Science, Coombe Healthcare Centre, Dublin, Ireland.

出版信息

Eur J Gen Pract. 2007;13(1):5-12. doi: 10.1080/14017430601049365.

DOI:10.1080/14017430601049365
PMID:17366287
Abstract

OBJECTIVE

In Ireland, general practice is increasingly providing long-term care for injecting drug users, 62-81% of whom are infected with hepatitis C (HCV). Clinical guidelines for the management of HCV among drug users have recently been developed in Ireland, and this study aimed to describe HCV care among drug users attending general practice in the greater Dublin area, prior to the implementation of the clinical practice guidelines.

METHODS

The clinical records of 196 patients attending 25 general practices in the Eastern Regional Health Authority area of Ireland for methadone maintenance treatment were examined on site and anonymized data collected on HCV care processes.

RESULTS

Patients had been attending general practice for methadone maintenance treatment for a mean of 30.7 months, 72% were male and 51% had provided a urine sample testing positive for metabolites of drugs of abuse other than methadone in the previous 3 months. There was evidence that 77%, 69% and 60% had been screened for HCV, human immunodeficiency virus (HIV) and hepatitis B (HBV), respectively. Among those who had been tested, the prevalence of HCV, HIV and HBV infection was 69%, 10% and 11%, respectively. Of those known to be HCV positive, 36 (35%) had been tested for HCV-RNA (29 testing positive), 31 (30%) had been referred to a hepatology clinic, 24 (23%) had attended a clinic, 13 (13%) had a liver biopsy performed and three (3%) had started treatment for HCV.

CONCLUSION

While the majority of patients have been screened for blood-borne viruses, a minority of those infected with HCV have had subsequent investigations or treatment. New interventions to facilitate optimum care in this regard need to be considered.

摘要

目的

在爱尔兰,全科医疗越来越多地为注射吸毒者提供长期护理,其中62%至81%的人感染了丙型肝炎病毒(HCV)。爱尔兰最近制定了针对吸毒者丙型肝炎管理的临床指南,本研究旨在描述在临床实践指南实施之前,都柏林大区接受全科医疗的吸毒者的丙型肝炎护理情况。

方法

对爱尔兰东部地区卫生局辖区内25家全科诊所接受美沙酮维持治疗的196名患者的临床记录进行现场检查,并收集关于丙型肝炎护理过程的匿名数据。

结果

患者接受美沙酮维持治疗的平均时间为30.7个月,72%为男性,51%在过去3个月内提供的尿液样本中检测出除美沙酮以外的滥用药物代谢物呈阳性。有证据表明,分别有77%、69%和60%的患者接受了丙型肝炎病毒、人类免疫缺陷病毒(HIV)和乙型肝炎病毒(HBV)的筛查。在接受检测的患者中,丙型肝炎病毒、HIV和HBV感染率分别为69%、10%和11%。在已知丙型肝炎病毒呈阳性的患者中,36人(35%)接受了丙型肝炎病毒核糖核酸(HCV-RNA)检测(29人检测呈阳性),31人(30%)被转诊至肝病诊所,24人(23%)就诊于诊所,13人(13%)接受了肝活检,3人(3%)开始接受丙型肝炎治疗。

结论

虽然大多数患者接受了血源病毒筛查,但感染丙型肝炎病毒的少数患者随后进行了进一步检查或治疗。需要考虑在这方面促进最佳护理的新干预措施。

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