Miller S D, Pritchard D, Crowley J P
Department of Medicine, Brown University/Rhode Island Hospital, Providence.
Ann Allergy. 1992 Jan;68(1):27-9.
Acquired cold urticaria with a negative cold stimulation test has been described in seven patients in whom the standard ice cube test did not induce localized urticaria. Subsequent total body cold exposure induced a generalized urticaria. A patient with this syndrome is presented where blood histamine levels rose from 9 to 60 micrograms/dL after a negative local cold stimulation test and from 60 to 90 micrograms/dL after total body cold exposure. Urticaria occurred only after generalized cold exposure. Blood histamine levels following the ice cube test may represent a sensitive method to diagnose this form of atypical acquired cold urticaria, without subjecting the patient to the risk of anaphylaxis reported following total body cold exposure.
已有报道称，7例患者出现冷刺激试验阴性的获得性寒冷性荨麻疹，其标准冰块试验未诱发局部荨麻疹。随后全身冷暴露诱发了全身性荨麻疹。本文报告了1例该综合征患者，其局部冷刺激试验阴性后血组胺水平从9微克/分升升至60微克/分升，全身冷暴露后从60微克/分升升至90微克/分升。荨麻疹仅在全身冷暴露后出现。冰块试验后的血组胺水平可能是诊断这种非典型获得性寒冷性荨麻疹的一种敏感方法，而无需让患者承担全身冷暴露后所报道的过敏反应风险。
