Bozkurt Suheyla Uyar, Ahiskali Rengin, Kaya Handan, Demir Aslan, Ilker Yalcin
Department of Pathology, Marmara University School of Medicine, Istanbul, Turkey.
APMIS. 2007 Mar;115(3):259-62. doi: 10.1111/j.1600-0463.2007.apm_500.x.
Solitary fibrous tumors are rare spindle cell neoplasms usually arising in the pleura. They have, however, also been reported at extrapleural locations. Solitary fibrous tumor (SFT) of the kidney is rare. Despite its rarity, histological diagnosis of solitary fibrous tumor is crucial to avoid misdiagnosis with other more aggressive tumors arising in the kidney. We report a solitary fibrous tumor of the left kidney that presented as a malignant tumor in a 51-year-old woman, and include clinical and radiographic findings. The tumor was well circumscribed and composed of spindle cells in a collagenous stroma. Immunohistochemistry showed reactivity for vimentin, CD 34, BCL-2 protein and CD99. Immunohistochemical stains for cytokeratin, S-100, desmin, alpha-smooth muscle actin and HMB-45 were negative. A diagnosis of SFT was made based on light microscopy and immunohistochemistry.
孤立性纤维性肿瘤是一种罕见的梭形细胞肿瘤，通常起源于胸膜。然而，也有报道称其发生于胸膜外部位。肾孤立性纤维性肿瘤（SFT）较为罕见。尽管其罕见，但孤立性纤维性肿瘤的组织学诊断对于避免与肾脏发生的其他更具侵袭性的肿瘤误诊至关重要。我们报告一例左肾孤立性纤维性肿瘤，该肿瘤在一名51岁女性中表现为恶性肿瘤，并包括临床和影像学检查结果。肿瘤边界清晰，由胶原性间质中的梭形细胞组成。免疫组织化学显示波形蛋白、CD34、BCL-2蛋白和CD99呈阳性反应。细胞角蛋白、S-100、结蛋白、α-平滑肌肌动蛋白和HMB-45的免疫组织化学染色均为阴性。基于光学显微镜检查和免疫组织化学做出了SFT的诊断。
