使用羟基和甲氧基芳香醛对汉茨希合成产物进行气相色谱-质谱联用（GC-MS）和串联气相色谱-质谱联用（GC-MS-MS）分析。

Analyses by GC-MS and GC-MS-MS of the Hantzsch synthesis products using hydroxy- and methoxy-aromatic aldehydes.

作者信息

Núñez-Vergara Luis J, Navarrete-Encina P A, Salas S, Conde B, Carbajo J, Squella J A, Camargo C

机构信息

Laboratory of Bioelectrochemistry, Chile.

出版信息

J Pharm Biomed Anal. 2007 May 9;44(1):236-42. doi: 10.1016/j.jpba.2007.01.025. Epub 2007 Jan 21.

DOI:10.1016/j.jpba.2007.01.025

PMID:17367976

Abstract

EI mass spectra of products of the dihydropyridine Hantzsch synthesis using hydroxy and methoxy aldehydes as starting materials are reported. The reaction products (C-4 hydroxy- and methoxyphenyl-1,4-dihydropyridines and chromeno[3,4,c]-pyridines) were derivatized with N-methyl-N-(trimethylsilyl)-trifluoracetamide to be analyzed by gas chromatographic techniques. Fragmentation pathways for 1,4-dihydropyridines and chromeno-pyridines are proposed. The study provides (mainly through MS-MS technique) useful data for the confirmation of the structure of the compounds and also is a valuable tool for further analytical purposes to follow both photostability and reactivity studies with free radicals for these types of compounds.

摘要

报道了以羟基醛和甲氧基醛为起始原料的二氢吡啶汉茨希合成产物的电子轰击质谱。反应产物（C-4-羟基苯基-1,4-二氢吡啶、C-4-甲氧基苯基-1,4-二氢吡啶和色烯并[3,4,c]吡啶）用N-甲基-N-（三甲基硅基）-三氟乙酰胺进行衍生化，以便通过气相色谱技术进行分析。提出了1,4-二氢吡啶和色烯并吡啶的裂解途径。该研究（主要通过串联质谱技术）为化合物结构的确认提供了有用的数据，也是进一步进行分析的有价值工具，可用于跟踪这些类型化合物的光稳定性和自由基反应性研究。