Berthelot Cindy, Dickerson Mary C, Rady Peter, He Qin, Niroomand Farhad, Tyring Stephen K, Pandya Amit G
Medical School, University of Texas Southwestern Medical Center at Dallas, USA.
J Am Acad Dermatol. 2007 May;56(5):882-6. doi: 10.1016/j.jaad.2007.01.036. Epub 2007 Mar 26.
Epidermodysplasia verruciformis (EV) is a rare disorder characterized by widespread human papillomavirus infection and malignant transformation. EV may be caused by mutations of the genes EVER1 or EVER2, which are located on the EV1 locus, 17q25. We describe a patient with EV and a novel homozygous gene mutation of EVER2 gene who was treated successfully with topical imiquimod.
疣状表皮发育不良是一种罕见的疾病，其特征为广泛的人乳头瘤病毒感染和恶性转化。疣状表皮发育不良可能由位于17q25的EV1位点上的EVER1或EVER2基因突变引起。我们描述了一名患有疣状表皮发育不良且存在EVER2基因新的纯合基因突变的患者，该患者经局部应用咪喹莫特成功治愈。
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