Karande Pankaj, Jain Amit, Arora Anubhav, Ho Moon Jean, Mitragotri Samir
Department of Chemical Engineering, University of California, Santa Barbara, CA 93106, USA.
Eur J Pharm Sci. 2007 May;31(1):1-7. doi: 10.1016/j.ejps.2007.01.004. Epub 2007 Feb 2.
Certain mixtures of chemicals are known to synergistically enhance skin permeability to drugs. Here, we report on the transport enhancing properties of mixtures of an anionic surfactant, sodium lauroylsarcosinate (NLS) and a non-ionic surfactant, sorbitan monolaurate (S20) in 1:1 phosphate buffered saline (PBS):ethanol (EtOH) solvent. Effect of 44 different compositions of NLS:S20 on skin constituents was probed by Fourier transform-infrared (FT-IR) spectroscopy while behavior of surfactant molecules in the solvent system was probed by FT-IR and NMR spectroscopy. No aggregation of NLS or S20 alone was observed in 1:1 PBS:EtOH at all concentrations studied (0-2%, w/v). However, mixtures of NLS and S20 resulted in micelle-like aggregates at certain specific compositions. Interestingly, compositions with increased aggregation showed resemblance to those that exhibited highest skin permeabilization.
已知某些化学混合物可协同增强皮肤对药物的渗透性。在此，我们报告了在1:1磷酸盐缓冲盐水（PBS）：乙醇（EtOH）溶剂中，阴离子表面活性剂月桂酰肌氨酸钠（NLS）与非离子表面活性剂单月桂酸山梨醇酯（S20）混合物的转运增强特性。通过傅里叶变换红外（FT-IR）光谱探究了44种不同组成的NLS:S20对皮肤成分的影响，同时通过FT-IR和NMR光谱探究了表面活性剂分子在溶剂体系中的行为。在所有研究浓度（0-2%，w/v）下，在1:1 PBS:EtOH中均未观察到单独的NLS或S20聚集。然而，NLS和S20的混合物在某些特定组成下会形成类似胶束的聚集体。有趣的是，聚集增加的组成与表现出最高皮肤通透性的组成相似。
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