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新鲜骨软骨移植治疗股骨髁剥脱性骨软骨炎

Fresh osteochondral allografting in the treatment of osteochondritis dissecans of the femoral condyle.

作者信息

Emmerson Bryan C, Görtz Simon, Jamali Amir A, Chung Christine, Amiel David, Bugbee William D

机构信息

Department of Orthopaedic Surgery, University of California San Diego, La Jolla, CA 92093-0630, USA.

出版信息

Am J Sports Med. 2007 Jun;35(6):907-14. doi: 10.1177/0363546507299932. Epub 2007 Mar 16.

Abstract

BACKGROUND

The treatment of osteochondritis dissecans in the adult knee can be challenging. As part of our comprehensive treatment program, fresh osteochondral allografts have been used in the surgical management of osteochondritis dissecans of the femoral condyle.

HYPOTHESIS

Fresh osteochondral allograft transplantation will provide a successful surgical treatment for osteochondritis dissecans of the femoral condyle.

STUDY DESIGN

Case series; Level of evidence, 4.

METHODS

Sixty-six knees in 64 patients underwent fresh osteochondral allografting for the treatment of osteochondritis dissecans. Each patient was evaluated both preoperatively and postoperatively using an 18-point modified D'Aubigné and Postel scale. Subjective assessment was performed using a patient questionnaire. Radiographs were evaluated preoperatively and postoperatively.

RESULTS

Mean follow-up was 7.7 years (range, 2-22 years). There were 45 men and 19 women with a mean age of 28.6 years (range, 15-54 years). All patients had undergone previous surgery. Forty-one lesions involved the medial femoral condyle, and 25 involved the lateral femoral condyle. All were osteochondritis dissecans type 3 or 4. The mean allograft size was 7.5 cm(2). One knee was lost to follow-up. Of the remaining 65 knees, 47 (72%) were rated good/excellent, 7 (11%) were rated fair, and 1 (2%) was rated poor. Ten patients (15%) underwent reoperation. The mean clinical score improved from 13.0 preoperatively to 16.4 postoperatively (P < .01). Fifty-nine of 64 patients completed questionnaires. Subjective knee function improved from a mean of 3.4 to 8.4 on a 10-point scale (P < .01).

CONCLUSION

With greater than 70% good or excellent results, fresh osteochondral allograft transplantation is a successful surgical treatment for osteochondritis dissecans of the femoral condyle.

摘要

背景

成人膝关节剥脱性骨软骨炎的治疗具有挑战性。作为我们综合治疗方案的一部分,新鲜骨软骨异体移植已被用于股骨髁剥脱性骨软骨炎的手术治疗。

假设

新鲜骨软骨异体移植将为股骨髁剥脱性骨软骨炎提供成功的手术治疗。

研究设计

病例系列;证据等级,4级。

方法

64例患者的66个膝关节接受了新鲜骨软骨异体移植治疗剥脱性骨软骨炎。每位患者术前和术后均使用18分改良的达布尼和波斯泰尔量表进行评估。使用患者问卷进行主观评估。术前和术后对X线片进行评估。

结果

平均随访7.7年(范围2 - 22年)。有45名男性和19名女性,平均年龄28.6岁(范围15 - 54岁)。所有患者均曾接受过手术。41处病损累及内侧股骨髁,25处累及外侧股骨髁。均为3型或4型剥脱性骨软骨炎。异体移植平均大小为7.5平方厘米。1个膝关节失访。在其余65个膝关节中,47个(72%)评定为良好/优秀,7个(11%)评定为中等,1个(2%)评定为差。10例患者(15%)接受了再次手术。临床评分平均从术前的13.0提高到术后的16.4(P < .01)。64例患者中有59例完成了问卷。主观膝关节功能在10分制量表上平均从3.4提高到8.4(P < .01)。

结论

新鲜骨软骨异体移植治疗股骨髁剥脱性骨软骨炎的优良率大于70%,是一种成功的手术治疗方法。

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