苦参根中抑制钠-葡萄糖协同转运蛋白（SGLT）的黄酮类化合物。

Na+-glucose cotransporter (SGLT) inhibitory flavonoids from the roots of Sophora flavescens.

作者信息

Sato Seizo, Takeo Jiro, Aoyama Chihiro, Kawahara Hiroyuki

机构信息

Central Research Laboratory, Nippon Suisan Kaisha, Ltd, 559-6 Kitano-machi, Hachioji, Tokyo 192-0906, Japan.

出版信息

Bioorg Med Chem. 2007 May 15;15(10):3445-9. doi: 10.1016/j.bmc.2007.03.011. Epub 2007 Mar 12.

DOI:10.1016/j.bmc.2007.03.011

PMID:17374486

Abstract

The methanol extract of Sophora flavescens, which is used in traditional Chinese medicine (sophorae radix), showed potent Na(+)-glucose cotransporter (SGLT) inhibitory activity. Our search for active components identified many well-known flavonoid antioxidants: kurarinone, sophoraflavanone G, kushenol K, and kushenol N.

摘要

苦参（中药苦参根）的甲醇提取物显示出强大的钠-葡萄糖共转运蛋白（SGLT）抑制活性。我们对活性成分的研究鉴定出了许多著名的类黄酮抗氧化剂：苦参醌、苦参黄酮G、苦参醇K和苦参醇N。