Higgins N Patrick
Department of Biochemistry and Molecular Genetics, University of Alabama at Birmingham, Birmingham, AL 93294-0024, USA.
Mol Microbiol. 2007 Apr;64(1):1-4. doi: 10.1111/j.1365-2958.2007.05641.x.
In this issue of Molecular Microbiology, Hendrickson and Lawrence analyse the sequence of bacterial genomes to map the historical traffic pattern of chromosome replication. Their surprising conclusion is that most forks terminate at the dif site rather than at the Tus/Ter sites where most investigators have concluded termination occurs most frequently. What make this analysis novel are the methods and the revisionist hypotheses for how and why forks might stop at dif.
在本期《分子微生物学》中,亨德里克森和劳伦斯分析了细菌基因组序列,以绘制染色体复制的历史移动模式。他们令人惊讶的结论是,大多数复制叉在dif位点终止,而不是在大多数研究人员认为终止最常发生的Tus/Ter位点。这项分析的新颖之处在于其方法以及关于复制叉如何以及为何会在dif位点停止的修正主义假设。