Bolcal C, Akay H T, Bingol H, Doganci S, Yildirim V, Yenicesu M, Demirkilic U, Tatar H
Department of Cardiovascular Surgery, Gülhane Military Medical Academy, Ankara, Turkey.
Thorac Cardiovasc Surg. 2007 Mar;55(2):89-93. doi: 10.1055/s-2006-924571.
We aimed to show the impact of leukodepletion on renal function in patients undergoing on-pump coronary revascularization.
Fifty patients awaiting elective on-pump coronary revascularization with normal preoperative cardiac functions and with plasma creatinine levels ranging between 1.5 and 2.0 mg/dL were prospectively randomized into two groups: on-pump CABG with (group A: n = 25) and without leukodepletion (group B, n = 25). Renal glomerular and tubular injury were assessed by urinary alpha glutathione s-transferase (GST), plasma creatinine, and blood urea nitrogen (BUN) levels.
The patients consisted of 14 females and 36 males with a mean age of 57.6 +/- 5.3 years. In the leukodepletion group, the mean levels of creatinine, BUN and urinary GST were found to be decreased on the first, third and fifth postoperative days compared with the control group. There was no mortality. Three patients in the control group needed postoperative dialysis.
Patients with renal dysfunction undergoing on-pump CABG surgery seem to benefit from leukodepletion as a measure to prevent tubular damage and renal impairment compared with a control group.
我们旨在展示白细胞滤除术对接受体外循环冠状动脉血运重建术患者肾功能的影响。
五十例等待择期体外循环冠状动脉血运重建术、术前心功能正常且血浆肌酐水平在1.5至2.0mg/dL之间的患者被前瞻性随机分为两组：接受白细胞滤除术的体外循环冠状动脉搭桥术组（A组：n = 25）和未接受白细胞滤除术组（B组，n = 25）。通过尿α-谷胱甘肽S-转移酶（GST）、血浆肌酐和血尿素氮（BUN）水平评估肾小球和肾小管损伤。
患者包括14名女性和36名男性，平均年龄为57.6±5.3岁。在白细胞滤除术组中，与对照组相比，术后第1天、第3天和第5天的肌酐、BUN和尿GST平均水平均有所下降。无死亡病例。对照组有3名患者需要术后透析。
与对照组相比，肾功能不全的患者在接受体外循环冠状动脉搭桥手术时，白细胞滤除术作为预防肾小管损伤和肾功能损害的一种措施似乎有益。
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