甘丙肽在单神经病大鼠下丘脑弓状核伤害性调节中的作用

Involvement of galanin in nociceptive regulation in the arcuate nucleus of hypothalamus in rats with mononeuropathy.

作者信息

Gu Xing-Long, Sun Yan-Gang, Yu Long-Chuan

机构信息

Neurobiology Laboratory and National Laboratory of Biomembrane and Membrane Biotechnology, Center for Brain and Cognitive Science, College of Life Sciences, Peking University, Beijing 100871, People's Republic of China.

出版信息

Behav Brain Res. 2007 May 16;179(2):331-5. doi: 10.1016/j.bbr.2007.02.033. Epub 2007 Feb 25.

DOI:10.1016/j.bbr.2007.02.033

PMID:17383023

Abstract

The hindpaw withdrawal latencies (HWLs) to noxious thermal and mechanical stimulation increased significantly after intra-hypothalamic arcuate nucleus (ARC) injection of galanin in mononeuropathic rats, while intra-ARC injection of the putative antagonist of galanin receptors markedly reduced the HWLs. The number of galaninergic neurons in the ARC increased in rats with mononeuropathy than that in normal rats. The results demonstrated that both endogenous and exogenous galanin were involved in the regulation of nociception in the ARC of rats with peripheral nerve injury.

摘要

在单神经病大鼠下丘脑弓状核（ARC）内注射甘丙肽后，其对伤害性热刺激和机械刺激的后爪撤离潜伏期（HWLs）显著增加，而在ARC内注射甘丙肽受体的假定拮抗剂则明显缩短了HWLs。单神经病大鼠ARC中甘丙肽能神经元的数量比正常大鼠增加。结果表明，内源性和外源性甘丙肽均参与了周围神经损伤大鼠ARC中伤害感受的调节。