2型糖尿病高血压患者动态血压监测的可重复性

Reproducibility of ambulatory blood pressure monitoring in hypertensive patients with type 2 diabetes mellitus.

作者信息

Felício João Soares, Pacheco Juliana Torres, Ferreira Sandra Roberta, Plavnik Frida, Kohlmann Oswaldo, Ribeiro Artur Beltrame, Zanella Maria Tereza

机构信息

Divisão de Nefrologia e Endocrinologia, UNIFESP, São Paulo, SP, Brazil.

出版信息

Arq Bras Cardiol. 2007 Feb;88(2):206-11. doi: 10.1590/s0066-782x2007000200012.

DOI:10.1590/s0066-782x2007000200012

PMID:17384839

Abstract

OBJECTIVE

To evaluate the reproducibility of ambulatory blood pressure monitoring (ABPM) (SpaceLabs-90207) and placebo effect on ABPM.

METHODS

Blood pressure was measured in the office and over two ABPM periods with an interval from one to ten months (mean 4.9 months), in 26 patients with type 2 diabetes mellitus and hypertension. Eleven patients (G1) had two ABPMs without taking antihypertensive drugs for 15 days, whereas G2 (N=15) had the second ABPM after administration of a placebo for 15 days.

RESULTS

In the evaluation of the coefficient of variation (CV) of diurnal (awake) systolic BP (DSBP), of diurnal (awake) diastolic BP (DDBP), of 24-hour systolic BP (24hSBP) and of 24-hour diastolic BP (24hDBP), the values found were 4.6%, 3.9%, 5.0%, 4.0% for G1 and 4.3%, 5.1%, 3.7%, 5.1% for G2 respectively. We also determined the CV of nocturnal (sleep) systolic and diastolic BP (NSBP and NDBP) for G1 (7.7%; 8.2%) and G2 (5.6%; 6.3%). Heart rate CV during alertness and sleep were: G1=5.9% and 9.0%; G2=6.9% and 5.8% respectively. When the total number of 'patients was analyzed, all variables showed a strong correlation between the first and second ABPM measurements (DSBP, r = 0.76; P < 0.001; DDBP, r = 0.65; p < 0.001; 24hSBP, r = 0.77; p < 0.001; 24hDBP, r = 0.70; p < 0.001; NSBP, r = 0.62; p < 0.001; NDBP, r = 0.52; p < 0.01). Office systolic and diastolic BP and 24hSBP and 24hDBP also showed correlation (r = 0.65; p < 0.001; r = 0.57; p < 0.01).

CONCLUSION

Mean of pressure levels measured by ABPM presented good reproducibility and were not affected by placebo.

摘要

目的

评估动态血压监测（ABPM）（太空实验室90207型）的可重复性以及安慰剂对ABPM的影响。

方法

对26例2型糖尿病合并高血压患者在诊室测量血压，并在两个ABPM阶段进行测量，间隔时间为1至10个月（平均4.9个月）。11例患者（G1组）在未服用抗高血压药物15天后进行两次ABPM测量，而G2组（n = 15）在服用安慰剂15天后进行第二次ABPM测量。

结果

在评估日间（清醒）收缩压（DSBP）、日间（清醒）舒张压（DDBP）、24小时收缩压（24hSBP）和24小时舒张压（24hDBP）的变异系数（CV）时，G1组的值分别为4.6%、3.9%、5.0%、4.0%，G2组分别为4.3%、5.1%、3.7%、5.1%。我们还确定了G1组（7.7%；8.2%）和G2组（5.6%；6.3%）夜间（睡眠）收缩压和舒张压（NSBP和NDBP）的CV。警觉和睡眠期间的心率CV分别为：G1组=5.9%和9.0%；G2组=6.9%和5.8%。对所有患者进行分析时，所有变量在第一次和第二次ABPM测量之间均显示出强相关性（DSBP，r = 0.76；P < 0.001；DDBP，r = 0.65；p < 0.001；24hSBP，r = 0.77；p < 0.001；24hDBP，r = 0.70；p < 0.001；NSBP，r = 0.62；p < 0.001；NDBP，r = 0.52；p < 0.01）。诊室收缩压和舒张压以及24hSBP和24hDBP也显示出相关性（r = 0.65；p < 0.001；r = 0.57；p < 0.01）。