Zordan E, Amirouche F
Biomechanics Research Laboratory, University of Illinois at Chicago, Chicago, IL 60607, USA.
Proc Inst Mech Eng H. 2007 Feb;221(2):143-51. doi: 10.1243/09544119JEIM152.
The newly designed micropump model proposed consists of a valveless double chamber pump completely simulated and optimized for drug delivery conditions. First, the inertia force and viscous loss in relation to actuation, pressure, and frequency is considered, and then a model of the nozzle/diffuser elements is introduced. The value of the flowrate obtained from the first model is then used to determine the loss coefficients starting from geometrical properties and flow velocity. From the developed model IT analysis is performed to predict the micropump performance based on the actuation parameters and no energy loss. A single-chamber pump with geometrical dimensions equal to each of the chambers of the double-chamber pump was also developed, and the results from both models are then compared for equally applied actuation pressure and frequency. Results show that the proposed design gives a maximum flow working frequency that is about 30 per cent lower than the single chamber design, with a maximum flowrate that is 140 per cent greater than that of the single chamber. Finally, the influences of geometrical properties on flowrate, maximum flow frequency, loss coefficients, and membrane strain are examined. The results show that the nozzle/ diffuser initial width and chamber side length are the most critical dimensions of the design.
所提出的新设计微泵模型由一个无阀双腔泵组成,该泵针对药物输送条件进行了完全模拟和优化。首先,考虑了与驱动、压力和频率相关的惯性力和粘性损失,然后引入了喷嘴/扩散器元件的模型。从第一个模型获得的流量值随后用于根据几何特性和流速确定损失系数。基于所开发的模型进行IT分析,以根据驱动参数预测微泵性能且无能量损失。还开发了一个几何尺寸与双腔泵的每个腔室相等的单腔泵,然后在相同的驱动压力和频率下比较两个模型的结果。结果表明,所提出的设计给出的最大流量工作频率比单腔设计低约30%,最大流量比单腔设计大140%。最后,研究了几何特性对流量、最大流量频率、损失系数和膜应变的影响。结果表明,喷嘴/扩散器初始宽度和腔室边长是该设计中最关键的尺寸。