Shim H B, Kim Y D, Jung T Y, Lee J K, Ku J H
Department of Urology, Seoul Veterans Hospital, Seoul, Korea.
Spinal Cord. 2008 Jan;46(1):11-5. doi: 10.1038/sj.sc.3102051. Epub 2007 Mar 27.
Prospective, cross-sectional, case-control study.
Outpatient department in Seoul, Korea.
To assess prostate volume and serum prostate-specific antigen (PSA) levels in Korean men with spinal cord injury (SCI).
A total of 31 SCI patients with ages ranging between 45 and 81 years old (median age, 58 years) were studied. Thirty-one age-matched individuals without SCI were enrolled in the study as controls. We tested PSA levels and performed transrectal ultrasonographies on all enrolled patients. Of the patients with SCI, 20 were evaluated for testosterone, luteinizing hormone (LH), and follicle-stimulating hormone (FSH) levels.
Serum PSA levels and prostate volume parameters in the two groups had similar values: the median (5th-95th percentiles) serum PSA level was 1.56 ng/ml (0.12-9.77) for SCI patients and 1.04 ng/ml (0.50-2.98) for controls (P=0.481), whereas the median (5th-95th percentiles) prostate volume was 18.33 ml (10.16-76.78) for SCI patients and 20.80 ml (14.23-41.22) for controls (P=0.072). No significant differences were found when serum PSA levels and prostate volumes were compared according to SCI patient injury characteristics. Testosterone levels were lower than the normal range in 7 SCI patients (35%), LH was higher than the normal range in 10 SCI patients (20%), and FSH was higher than the normal range in eight SCI patients (40%). We observed an age-related increase in FSH levels (r=0.634, P=0.004), although hormone levels did not correlate with serum PSA levels and prostate volume parameters.
According to our results, serum PSA levels and prostate volume in Korean SCI patients are not different from those in uninjured men and are not affected by injury characteristics.
前瞻性横断面病例对照研究。
韩国首尔的门诊部。
评估韩国脊髓损伤（SCI）男性的前列腺体积和血清前列腺特异性抗原（PSA）水平。
共研究了31例年龄在45至81岁之间（中位年龄58岁）的SCI患者。31名年龄匹配的无SCI个体作为对照纳入研究。我们检测了所有纳入患者的PSA水平并进行了经直肠超声检查。在SCI患者中，对20例患者评估了睾酮、促黄体生成素（LH）和促卵泡生成素（FSH）水平。
两组的血清PSA水平和前列腺体积参数值相似：SCI患者的中位（第5 - 95百分位数）血清PSA水平为1.56 ng/ml（0.12 - 9.77），对照组为1.04 ng/ml（0.50 - 2.98）（P = 0.481）；而SCI患者的中位（第5 - 95百分位数）前列腺体积为18.33 ml（10.16 - 76.78），对照组为20.80 ml（14.23 - 41.22）（P = 0.072）。根据SCI患者损伤特征比较血清PSA水平和前列腺体积时，未发现显著差异。7例SCI患者（35%）的睾酮水平低于正常范围，10例SCI患者（20%）的LH高于正常范围，8例SCI患者（40%）的FSH高于正常范围。我们观察到FSH水平随年龄增加（r = 0.634，P = 0.004），尽管激素水平与血清PSA水平和前列腺体积参数无关。
根据我们的结果，韩国SCI患者的血清PSA水平和前列腺体积与未受伤男性无异，且不受损伤特征影响。
