Gokhale Rajesh S, Saxena Priti, Chopra Tarun, Mohanty Debasisa
National Institute of Immunology, Aruna Asaf Ali Marg, New Delhi, 110 067, India.
Nat Prod Rep. 2007 Apr;24(2):267-77. doi: 10.1039/b616817p. Epub 2007 Feb 28.
The cell envelope of Mycobacterium tuberculosis (Mtb) is a treasure house of a variety of biologically active molecules with fascinating architectures. The decoding of the genetic blueprint of Mtb in recent years has provided the impetus for dissecting the metabolic pathways involved in the biosynthesis of lipidic metabolites. The focus of the Highlight is to emphasize the functional role of polyketide synthase (PKS) proteins in the biosynthesis of complex mycobacterial lipids. The catalytic as well as mechanistic versatility of PKS. in generating metabolic diversity and the significance of recently discovered fatty acyl-AMP ligases in establishing "biochemical crosstalk" between fatty acid synthases (FASs) and PKSs is described. The phenotypic heterogeneity and remodeling of the mycobacterial cell wall in its aetiopathogenesis is discussed.
结核分枝杆菌（Mtb）的细胞包膜是各种具有迷人结构的生物活性分子的宝库。近年来对Mtb遗传蓝图的解码为剖析脂质代谢产物生物合成中涉及的代谢途径提供了动力。本综述的重点是强调聚酮合酶（PKS）蛋白在复杂分枝杆菌脂质生物合成中的功能作用。描述了PKS在产生代谢多样性方面的催化以及机制多样性，以及最近发现的脂肪酰-AMP连接酶在脂肪酸合酶（FAS）和PKS之间建立“生化串扰”的意义。还讨论了分枝杆菌细胞壁在其发病机制中的表型异质性和重塑。
