Chaudhry Priyanka, Schoenen Frank, Neuenswander Benjamin, Lushington Gerald H, Aubé Jeffrey
Department of Medicinal Chemistry, University of Kansas, 1251 Wescoe Hall Drive, Lawrence, Kansas 66045, USA.
J Comb Chem. 2007 May-Jun;9(3):473-6. doi: 10.1021/cc060159t. Epub 2007 Mar 29.
The reactions of 1,2- and 1,3-hydroxyalkyl azides and aldehydes in the presence of Lewis acid result in the one-step construction of oxazolines and dihydrooxazines, respectively. The reaction was adapted to parallel synthesis using a polymer-bound phosphine to scavenge excess hydroxyalkyl azide. Thus, a 60-member library of various disubstituted oxazolines and di- and trisubstituted dihydrooxazines was generated.
在路易斯酸存在下,1,2-和1,3-羟烷基叠氮化物与醛反应,分别一步构建恶唑啉和二氢恶嗪。该反应适用于使用聚合物负载的膦清除过量羟烷基叠氮化物的平行合成。因此,生成了一个包含各种二取代恶唑啉以及二取代和三取代二氢恶嗪的60个成员的文库。