de Greef Michiel, Zard Samir Z
Laboratoire de Synthèse Organique associé au C.N.R.S., Ecole Polytechnique, 91128 Palaiseau, France.
Org Lett. 2007 Apr 26;9(9):1773-6. doi: 10.1021/ol070488+. Epub 2007 Mar 29.
[reaction: see text] Functionalization of S-(3-chloro-2-oxo-propyl)-O-ethyl xanthate 1 by two consecutive xanthate transfer reactions, followed by spirocyclization of the resulting dihydroxy ketones, provides a flexible and highly convergent access to diversely substituted spiroketals, containing five-, six-, and seven-membered rings.
[反应:见正文] 通过连续两次黄原酸酯转移反应对S-(3-氯-2-氧代丙基)-O-乙基黄原酸酯1进行官能化,然后将所得二羟基酮进行螺环化反应,可灵活且高效地合成具有五、六和七元环的多种取代螺缩酮。