关于OLR1与奶牛乳脂肪性状之间关联的更多支持证据。
Additional support for an association between OLR1 and milk fat traits in cattle.
作者信息
Khatib H, Rosa G J M, Weigel K, Schiavini F, Santus E, Bagnato A
机构信息
Department of Dairy Science, University of Wisconsin, Madison, WI 53706, USA.
出版信息
Anim Genet. 2007 Jun;38(3):308-10. doi: 10.1111/j.1365-2052.2007.01584.x. Epub 2007 Apr 2.
The bovine oxidized LDL receptor 1 (OLR1) was chosen as a candidate gene for association tests with milk composition traits. Genotyping of 773 Italian Brown Swiss for a SNP at position 8232 in OLR1 (NW_215807:g.8232C>A) revealed a frequency of 0.95 for the g.8232C allele. The University of Wisconsin Holstein resource population was genotyped for the OLR1 NW_215807:g.[7160C>T; 7161A>G; 8232C>A] SNPs, and four haplotypes were inferred based on the genotypes of sires and their daughters. Oxidized LDL receptor 1 haplotypes were significantly associated with fat percentage (P = 0.0015). Haplotype [C; A; C] was associated with a significant increase in fat percentage when compared with the other haplotypes.
牛氧化型低密度脂蛋白受体1（OLR1）被选为与牛奶成分性状进行关联测试的候选基因。对773头意大利褐牛进行OLR1基因第8232位单核苷酸多态性（SNP，NW_215807:g.8232C>A）基因分型，结果显示g.8232C等位基因频率为0.95。对威斯康星大学荷斯坦牛资源群体进行OLR1基因NW_215807:g.[7160C>T; 7161A>G; 8232C>A] SNP基因分型，并根据公牛及其女儿的基因型推断出四种单倍型。氧化型低密度脂蛋白受体1单倍型与乳脂率显著相关（P = 0.0015）。与其他单倍型相比，单倍型[C; A; C]与乳脂率显著升高有关。
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