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一种用于乳腺钼靶摄影几何结构中电阻抗断层成像的乳腺癌成像重建算法。

A reconstruction algorithm for breast cancer imaging with electrical impedance tomography in mammography geometry.

作者信息

Choi Myoung Hwan, Kao Tzu-Jen, Isaacson David, Saulnier Gary J, Newell Jonathan C

机构信息

Department of Electrical and Electronics Engineering, Kangwon National University, 192-1, Hyoza 2 dong, Chunchon, Kangwondo, Korea.

出版信息

IEEE Trans Biomed Eng. 2007 Apr;54(4):700-10. doi: 10.1109/TBME.2006.890139.

Abstract

The conductivity and permittivity of breast tumors are known to differ significantly from those of normal breast tissues, and electrical impedance tomography (EIT) is being studied as a modality for breast cancer imaging to exploit these differences. At present, X-ray mammography is the primary standard imaging modality used for breast cancer screening in clinical practice, so it is desirable to study EIT in the geometry of mammography. This paper presents a forward model of a simplified mammography geometry and a reconstruction algorithm for breast tumor imaging using EIT techniques. The mammography geometry is modeled as a rectangular box with electrode arrays on the top and bottom planes. A forward model for the electrical impedance imaging problem is derived for a homogeneous conductivity distribution and is validated by experiment using a phantom tank. A reconstruction algorithm for breast tumor imaging based on a linearization approach and the proposed forward model is presented. It is found that the proposed reconstruction algorithm performs well in the phantom experiment, and that the locations of a 5-mm-cube metal target and a 6-mm-cube agar target could be recovered at a target depth of 15 mm using a 32 electrode system.

摘要

众所周知,乳腺肿瘤的电导率和介电常数与正常乳腺组织有显著差异,电阻抗断层成像(EIT)作为一种利用这些差异进行乳腺癌成像的模态正在被研究。目前,X射线乳腺摄影是临床实践中用于乳腺癌筛查的主要标准成像模态,因此在乳腺摄影的几何结构中研究EIT是很有必要的。本文提出了一种简化乳腺摄影几何结构的正向模型以及一种使用EIT技术进行乳腺肿瘤成像的重建算法。乳腺摄影几何结构被建模为一个在顶部和底部平面带有电极阵列的长方体。针对均匀电导率分布推导了电阻抗成像问题的正向模型,并通过使用模拟水槽进行实验验证。提出了一种基于线性化方法和所提出的正向模型的乳腺肿瘤成像重建算法。结果发现,所提出的重建算法在模拟实验中表现良好,使用32电极系统在目标深度为15毫米时能够恢复5毫米立方体金属靶和6毫米立方体琼脂靶的位置。

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