英格兰和威尔士老年人抑郁症患病率：医学研究委员会认知功能与衰老研究

Prevalence of depression in older people in England and Wales: the MRC CFA Study.

作者信息

McDougall Fiona A, Kvaal Kari, Matthews Fiona E, Paykel Eugene, Jones Peter B, Dewey Michael E, Brayne Carol

机构信息

Department of Public Health and Primary Care, Cambridge University, UK.

出版信息

Psychol Med. 2007 Dec;37(12):1787-95. doi: 10.1017/S0033291707000372. Epub 2007 Apr 4.

DOI:10.1017/S0033291707000372

PMID:17407617

Abstract

BACKGROUND

Depression in old age is an important public health problem. The aims of this study were to report the prevalence of depression in the Medical Research Council Cognitive Function and Ageing Study (MRC CFAS), a community-based, cohort.

METHOD

Following screening of 13 004 people aged 65 and over from a population base, a stratified random subsample of 2640 participants received the Geriatric Mental State (GMS) examination and were diagnosed using the Automated Geriatric Examination for Computer-Assisted Taxonomy (AGECAT) algorithm.

RESULTS

The prevalence of depression was 8.7% [95% confidence interval (CI) 7.3-10.2], increasing to 9.7% if subjects with concurrent dementia were included. Depression was more common in women (10.4%) than men (6.5%) and was associated with functional disability, co-morbid medical disorder, and social deprivation. Prevalence remained high into old age, but after adjustment for other associated factors, it was lower in the older age groups.

CONCLUSIONS

The prevalence of depression in the elderly is high and remains high into old age, perhaps due to increased functional disability.

摘要

背景

老年抑郁症是一个重要的公共卫生问题。本研究旨在报告医学研究委员会认知功能与衰老研究（MRC CFAS，一项基于社区的队列研究）中抑郁症的患病率。

方法

从总体人群中筛选出13004名65岁及以上的老人后，对2640名参与者进行分层随机抽样，让他们接受老年精神状态（GMS）检查，并使用计算机辅助分类自动老年检查（AGECAT）算法进行诊断。

结果

抑郁症的患病率为8.7%[95%置信区间（CI）7.3 - 10.2]，若将同时患有痴呆症的受试者纳入计算，患病率则升至9.7%。抑郁症在女性（10.4%）中比男性（6.5%）更为常见，且与功能残疾、合并内科疾病及社会剥夺相关。抑郁症患病率在老年阶段一直居高不下，但在对其他相关因素进行调整后，年龄较大的组患病率较低。