Kopp Michael, Hermisson Joachim
Section of Evolutionary Biology, Department Biology II, Ludwig-Maximilian-University, Munich, Germany.
Genetics. 2007 May;176(1):715-9. doi: 10.1534/genetics.106.067215. Epub 2007 Apr 3.
We investigate adaptive evolution of a quantitative trait under stabilizing selection with a moving optimum. We characterize three regimes, depending on whether (1) the beneficial mutation rate, (2) the fixation time, or (3) the rate of environmental change is the limiting factor for adaptation. If the environment is rate limiting, mutations with a small phenotypic effect are preferred over large mutations, in contrast to standard theory.
我们研究了在具有移动最优值的稳定选择下数量性状的适应性进化。我们根据以下三个因素对三种情况进行了特征描述：（1）有益突变率，（2）固定时间，或（3）环境变化率是否为适应的限制因素。如果环境是速率限制因素，与标准理论相反，具有小表型效应的突变比大突变更受青睐。
