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1
The role of a minor groove spine of hydration in stabilizing poly(dA).poly(dT) against fluctuational interbase H-bond disruption in the premelting temperature regime.在预熔温度范围内，水化小沟脊在稳定聚（dA）·聚（dT）以防止波动的碱基间氢键破坏方面的作用。
Nucleic Acids Res. 1992 Feb 11;20(3):415-9. doi: 10.1093/nar/20.3.415.
2
Temperature dependence of the Raman spectrum of DNA. II. Raman signatures of premelting and melting transitions of poly(dA).poly(dT) and comparison with poly(dA-dT).poly(dA-dT).DNA拉曼光谱的温度依赖性。II. 聚（dA）·聚（dT）预熔解和熔解转变的拉曼特征以及与聚（dA-dT）·聚（dA-dT）的比较
Biopolymers. 2002 Mar;63(3):181-94. doi: 10.1002/bip.10022.
3
Synergistic effects in the melting of DNA hydration shell: melting of the minor groove hydration spine in poly(dA).poly(dT) and its effect on base pair stability.DNA水合壳层解链中的协同效应：聚（dA）·聚（dT）中小沟水合脊的解链及其对碱基对稳定性的影响。
Biophys J. 1993 May;64(5):1385-93. doi: 10.1016/S0006-3495(93)81504-2.
4
Premelting thermal fluctuational base pair opening probability of poly(dA).poly(dT) as predicted by the modified self-consistent phonon theory.修正的自洽声子理论预测的聚（dA）·聚（dT）的预熔热涨落碱基对打开概率
Biopolymers. 1991 Feb 5;31(2):139-48. doi: 10.1002/bip.360310202.
5
Structure of the hydration shells of oligo(dA-dT).oligo(dA-dT) and oligo(dA).oligo(dT) tracts in B-type conformation on the basis of Monte Carlo calculations.基于蒙特卡洛计算的B型构象中寡聚（dA-dT）·寡聚（dA-dT）和寡聚（dA）·寡聚（dT）片段水化壳的结构
Biopolymers. 1990;30(5-6):563-81. doi: 10.1002/bip.360300509.
6
Dependence of the hydration shell structure in the minor groove of the DNA double helix on the groove width as revealed by Monte Carlo simulation.通过蒙特卡罗模拟揭示DNA双螺旋小沟中水合壳层结构对沟宽的依赖性。
Biopolymers. 1991 Oct 15;31(12):1445-53. doi: 10.1002/bip.360311211.
7
Calculated enhancement of open base pair probability downstream of a (TATA)2 box.计算得出（TATA）2框下游开放碱基对概率的增强。
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8
Anomalous structure and properties of poly (dA).poly(dT). Computer simulation of the polynucleotide structure with the spine of hydration in the minor groove.聚（dA）·聚（dT）的异常结构与性质。小沟中带有水化脊的多核苷酸结构的计算机模拟。
Nucleic Acids Res. 1987 Jan 12;15(1):293-311. doi: 10.1093/nar/15.1.293.
9
Determination of base and backbone contributions to the thermodynamics of premelting and melting transitions in B DNA.确定碱基和主链对B型DNA预熔解和熔解转变热力学的贡献。
Nucleic Acids Res. 2002 Sep 1;30(17):3767-77. doi: 10.1093/nar/gkf471.
10
Temperature-dependent ultraviolet resonance Raman spectroscopy of the premelting state of dA.dT DNA.dA.dT DNA预熔解状态的温度依赖性紫外共振拉曼光谱
Biophys J. 1997 Apr;72(4):1512-20. doi: 10.1016/S0006-3495(97)78799-X.

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MoViES: molecular vibrations evaluation server for analysis of fluctuational dynamics of proteins and nucleic acids.MoViES：用于分析蛋白质和核酸波动动力学的分子振动评估服务器。
Nucleic Acids Res. 2004 Jul 1;32(Web Server issue):W679-85. doi: 10.1093/nar/gkh384.
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Structural insights into the effect of hydration and ions on A-tract DNA: a molecular dynamics study.水合作用和离子对A-DNA影响的结构洞察：一项分子动力学研究
Biophys J. 2003 Sep;85(3):1805-16. doi: 10.1016/S0006-3495(03)74609-8.
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Solvation of nucleosides in aqueous mixtures of organic solvents: relevance to DNA open basepairs.核苷在有机溶剂水混合体系中的溶剂化作用：与DNA开放碱基对的相关性
Biophys J. 2003 Aug;85(2):1111-27. doi: 10.1016/S0006-3495(03)74548-2.
4
Melting profile and temperature dependent binding constant of an anticancer drug daunomycin-DNA complex.
Eur Biophys J. 1996;24(4):203-12. doi: 10.1007/BF00205101.
5
Synergistic effects in the melting of DNA hydration shell: melting of the minor groove hydration spine in poly(dA).poly(dT) and its effect on base pair stability.DNA水合壳层解链中的协同效应：聚（dA）·聚（dT）中小沟水合脊的解链及其对碱基对稳定性的影响。
Biophys J. 1993 May;64(5):1385-93. doi: 10.1016/S0006-3495(93)81504-2.
6
Premelting base pair opening probability and drug binding constant of a daunomycin-poly d(GCAT).poly d(ATGC) complex.柔红霉素 - 聚d(GCAT).聚d(ATGC)复合物的预熔碱基对打开概率和药物结合常数
Biophys J. 1994 Mar;66(3 Pt 1):820-6. doi: 10.1016/s0006-3495(94)80858-6.

本文引用的文献

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Calculation of far-infrared absorption in polymer DNA.聚合物DNA中远红外吸收的计算
Phys Rev A Gen Phys. 1989 Mar 15;39(6):3173-3180. doi: 10.1103/physreva.39.3173.
2
Structure of a B-DNA dodecamer. III. Geometry of hydration.B型DNA十二聚体的结构。III. 水合作用的几何学
J Mol Biol. 1981 Sep 25;151(3):535-56. doi: 10.1016/0022-2836(81)90009-7.
3
Ordered water structure around a B-DNA dodecamer. A quantitative study.B型DNA十二聚体周围的有序水结构。一项定量研究。
J Mol Biol. 1983 Jan 5;163(1):129-46. doi: 10.1016/0022-2836(83)90033-5.
4
Premelting and the hydrogen-exchange open state in synthetic RNA duplexes.合成RNA双链体中的预熔解和氢交换开放状态。
Biopolymers. 1984 Nov;23(11 Pt 1):2099-125. doi: 10.1002/bip.360231102.
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Low-frequency lattice mode predictions in A-DNA compared to experimental observations and significance for A-to-B conformation change.与实验观察结果相比，A-DNA中的低频晶格模式预测以及A到B构象变化的意义。
Biopolymers. 1984 Sep;23(9):1795-8. doi: 10.1002/bip.360230912.
6
Poly(dA).poly(dT) exists in an unusual conformation under physiological conditions: propidium binding to poly(dA).poly(dT) and poly[d(A-T)].poly[d(A-T)].聚（dA）·聚（dT）在生理条件下以一种不寻常的构象存在：碘化丙啶与聚（dA）·聚（dT）以及聚[d（A - T）]·聚[d（A - T）]结合。
Biochemistry. 1985 Jul 16;24(15):3991-9. doi: 10.1021/bi00336a029.
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Regularities in formation of the spine of hydration in the DNA minor groove and its influence on the DNA structure.DNA小沟中水分子链形成的规律及其对DNA结构的影响。
FEBS Lett. 1985 Jul 1;186(1):98-102. doi: 10.1016/0014-5793(85)81347-8.
8
Anomalous structure and properties of poly (dA).poly(dT). Computer simulation of the polynucleotide structure with the spine of hydration in the minor groove.聚（dA）·聚（dT）的异常结构与性质。小沟中带有水化脊的多核苷酸结构的计算机模拟。
Nucleic Acids Res. 1987 Jan 12;15(1):293-311. doi: 10.1093/nar/15.1.293.
9
Poly(dA).poly(dT) is a B-type double helix with a distinctively narrow minor groove.聚（dA）·聚（dT）是一种具有明显狭窄小沟的B型双螺旋结构。
Nature. 1987;325(6107):821-3. doi: 10.1038/325821a0.
10
Monte-Carlo simulation of DNA duplex hydration. B and B' conformations of poly(dA).poly(dT) have different hydration shells.DNA双链水合作用的蒙特卡罗模拟。聚（dA）·聚（dT）的B和B'构象具有不同的水合壳层。
J Biomol Struct Dyn. 1988 Dec;6(3):575-86. doi: 10.1080/07391102.1988.10506508.

在预熔温度范围内，水化小沟脊在稳定聚（dA）·聚（dT）以防止波动的碱基间氢键破坏方面的作用。

The role of a minor groove spine of hydration in stabilizing poly(dA).poly(dT) against fluctuational interbase H-bond disruption in the premelting temperature regime.

作者信息

Chen Y Z, Prohofsky E W

机构信息

Department of Physics, Purdue University, West Lafayette, IN 47907.

出版信息

Nucleic Acids Res. 1992 Feb 11;20(3):415-9. doi: 10.1093/nar/20.3.415.

DOI:10.1093/nar/20.3.415
PMID:1741275
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC310401/
Abstract

Experimental estimates of the premelting Adenine-Thymine base pair opening probability for some B-DNA sequences are two orders of magnitude smaller than those of other B-DNA sequences. The AT pairs in the sequence with smaller open probability seem to be those that have a well defined spine of hydration in the minor groove. We show that this spine of hydration can significantly enhance the thermal stability of the base pairs to which they are attached. The effect of this spine of hydration coupled with the possible stabilization effect contributed from neighboring GC pairs can explain the differences in the observed AT pair opening probability for different AT containing B-DNA sequences.

摘要

一些B-DNA序列的腺嘌呤-胸腺嘧啶碱基对预熔解开放概率的实验估计值比其他B-DNA序列的小两个数量级。开放概率较小的序列中的AT碱基对似乎是那些在小沟中有明确水合骨架的碱基对。我们表明，这种水合骨架可以显著提高与其相连的碱基对的热稳定性。这种水合骨架的作用，再加上相邻GC碱基对可能产生的稳定作用，可以解释不同含AT的B-DNA序列中观察到的AT碱基对开放概率的差异。